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Anxiety tier list

72 supplements and medications people take for stress, calm and social anxiety, sorted by 8,283 first-hand reports. The tier is how many people say it helped, adjusted for sample size — S-tier means at least 80% even in the worst case the data allows. Only entries with 30+ reports for anxiety.

S
Very likely to help
Lithium Orotate98%of 80L-Theanine91%of 1,289Skullcap100%of 31Taurine93%of 209Kava93%of 196Propranolol94%of 101Aniracetam92%of 191Tianeptine95%of 62Bacopa92%of 142NAC90%of 301Magnesium90%of 295Bromantane96%of 46Ashwagandha88%of 881Phenibut89%of 419Kratom91%of 108Black Seed Oil94%of 52Magnolia Bark95%of 42Magnesium L-Threonate92%of 78Apigenin95%of 41Fasoracetam94%of 49Phosphatidylserine95%of 39Inositol90%of 100CBD88%of 185Agmatine89%of 121Picamilon93%of 45Passionflower92%of 50Lemon Balm88%of 121Holy Basil94%of 35Gotu Kola94%of 34
A
Likely to help
Magnesium Citrate87%of 69Magnesium Glycinate81%of 336Kanna88%of 42Piracetam86%of 57Psilocybin87%of 45Alprazolam85%of 60Polygala88%of 32GABA80%of 122Rhodiola78%of 200Sertraline86%of 37Saffron81%of 84Valerian Root86%of 36Clonazepam86%of 35Benzodiazepines84%of 45Green Tea Extract84%of 43
B
Often helps
Escitalopram83%of 41St. John's Wort82%of 44CBD Oil80%of 60Glycine78%of 60Gabapentin80%of 44Noopept76%of 79Omega-374%of 845-HTP72%of 71
C
Hit or miss
Alcohol73%of 52Pregnenolone77%of 30Buspirone76%of 33Pregabalin76%of 33Zinc75%of 36Lion's Mane68%of 65Phenylpiracetam71%of 41Vitamin D64%of 90Tongkat Ali69%of 35
D
Usually doesn't help — some make it worse
Tyrosine57%of 53Nicotine55%of 53Amphetamine38%of 56Lisdexamfetamine39%of 36THC33%of 96Modafinil30%of 87ALCAR33%of 42Methylphenidate29%of 48Caffeine16%of 240Bupropion15%of 34Coffee6%of 54
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Peptides and SARMs are not included in tier lists. Information only — not medical advice. How tiers are calculated