Find out what actually works — before you buy it.
PlainPill rates 3,159 supplements, nootropics, peptides and medications using 144,221 real-world user reports and the clinical research behind each one. No affiliate links in the rankings.
3,159 substances · 981 habits & methods · 144,221 user reports from 20,425 discussions · 1,679 with a research grade · how we rate
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Rankings by goal — sorted by how many people report it helped.
Top rated overall
The most-discussed substances (100+ reports with a clear outcome), ranked by how many people say they helped — adjusted for sample size, so hundreds of consistent reports beat a handful of glowing ones.
Backed by research and users
Most users say they helped, and there is a solid base of meta-analyses and clinical trials.
Where the numbers come from
User reports. Thousands of first-hand accounts from health and supplement communities are read one by one, recording what people took, how much, and what happened.
Clinical research. Each substance is matched against PubMed — meta-analyses, randomized trials, and what those reviews concluded.
No hand edits. Every score is computed, every quote links to its source, and sponsors never touch the rankings. Full methodology