PlainPill

Mood tier list

78 supplements and medications people take for mood, motivation and low mood, sorted by 7,644 first-hand reports. The tier is how many people say it helped, adjusted for sample size — S-tier means at least 80% even in the worst case the data allows. Only entries with 30+ reports for mood.

S
Very likely to help
Probiotics100%of 54Tianeptine95%of 148Ketamine97%of 62Bromantane95%of 74Saffron92%of 165Kanna94%of 84Curcumin96%of 45SAM-E92%of 114Lithium Orotate92%of 108Phenibut90%of 181Vitamin D88%of 393Memantine95%of 41Agmatine89%of 150Psilocybin90%of 110L-Tryptophan95%of 37Testosterone89%of 117Rhodiola87%of 219Omega-386%of 289Kratom87%of 142St. John's Wort87%of 127
A
Likely to help
Creatine87%of 125Pregnenolone94%of 31Mucuna Pruriens90%of 58Phenylpiracetam87%of 100Aniracetam87%of 1005-HTP84%of 214Taurine89%of 57Tyrosine83%of 259Polygala89%of 53Inositol88%of 60Dlpa91%of 35B Complex91%of 35Vitamin B1289%of 46Black Seed Oil90%of 39Vitamin B691%of 33LSD91%of 32Folate87%of 52Magnesium L-Threonate89%of 36Cognance90%of 31Magnesium82%of 119Glycine87%of 39Sabroxy88%of 33Uridine84%of 58L-Theanine77%of 223DHEA87%of 30Zinc81%of 68
B
Often helps
CBD85%of 34Maca83%of 41ALCAR78%of 89Lion's Mane75%of 124Caffeine74%of 137Escitalopram80%of 44Piracetam74%of 116Magnesium Glycinate74%of 103Noopept73%of 118Kava80%of 35Bupropion70%of 172Sulbutiamine76%of 46Tongkat Ali70%of 115
C
Hit or miss
NAC65%of 323Cistanche73%of 41Modafinil64%of 125Nicotine65%of 54Sertraline65%of 54THC64%of 58Fluoxetine65%of 48Ashwagandha53%of 446
D
Usually doesn't help — some make it worse
Citicoline57%of 46Alcohol60%of 30Bacopa51%of 106Amphetamine48%of 132Lisdexamfetamine50%of 82SSRI50%of 34Methylphenidate41%of 66Alpha-Gpc39%of 70Ssris39%of 41Melatonin32%of 37Choline22%of 51
Download as imageFull ranking for mood

Peptides and SARMs are not included in tier lists. Information only — not medical advice. How tiers are calculated