Yes, for most people. 87% of 127 people who reported on St. John's Wort for mood say it improved. 7% noticed no change and 6% say it got worse. That is about the typical result for mood (84% across 108 options).
Ranked #22 of 108 for mood.
“I am taking Saint John's Wort and Bacopa now to modulate my serotonin system, as well as trimethylglycine to help boost catecholamine production. That is helping a lot.”
“Didn't see any results with regular doses, so I took double the amount, and still nothing.”
“It worked after 3 weeks of supplementing but the feeling I got from it wasn't very pleasant. I felt very emotionally numbed from it and apathetic.”
“St Johns Wort gave me a few windows of feeling normal like I used to 15 years ago, which was amazing, but it started becoming unreliable.”
Conclusion: Our research supports the use of SJW as it reduced the number of depressive patients and their HAMD scores while having fewer risks and side effects than conventional medications.
Conclusion: The available evidence suggests that the hypericum extracts tested in the included trials a) are superior to placebo in patients with major depression; b) are similarly effective as standard antidepressants; c) and have fewer side effects than standard antidepressants. The association of country of origin and precision with effects sizes complicates the interpretation.
Conclusion: For patients with mild-to-moderate depression, St John's wort has comparable efficacy and safety when compared to SSRIs. Follow-up studies carried out over a longer duration should be planned to ascertain its benefits.
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