Best for mood

386 options people report for mood, motivation and low mood, ranked by the share of users who say it improved — weighted by how many reports there are.

Weight loss Appetite Focus Energy Sleep Anxiety Mood Memory Performance Recovery Pain & inflammation Digestion Libido Hormones Blood sugar Heart & lipids Skin & hair Immunity Longevity

Type:All Supplements Peptides Medications Substances Lifestyle Methods SARMs OtherResearch-backed only

44 results

149

PhenibutSubstance

Anxiety Mood Sleep

92% report better Mood

74 reports

MixedBResearch: Moderate

244

PsilocybinSubstance

Mood Anxiety Focus

93% report better Mood

59 reports

Mostly positiveAResearch: Strong

350

KratomSubstance

Mood Anxiety Energy

87% report better Mood

47 reports

MixedBResearch: Moderate

446

BromantaneSubstance

Energy Focus Mood

96% report better Mood

26 reports

Mostly positiveBResearch: Moderate

552

CaffeineSubstance

Energy Focus Anxiety

70% report better Mood

74 reports

MixedAResearch: Strong

654

LSDSubstance

Mood Focus Anxiety

84% report better Mood

19 reports

MixedAResearch: Strong

737

LSD MicrodoseSubstance

Mood Focus Anxiety

100% report better Mood

10 reports

Mostly positiveBResearch: Moderate

836

CannabisSubstance

Sleep Mood Anxiety

67% report better Mood

21 reports

MixedAResearch: Strong

946

NicotineSubstance

Focus Energy Mood

57% report better Mood

28 reports

MixedAResearch: Strong

1054

CoffeeSubstance

Energy Focus Anxiety

59% report better Mood

22 reports

MixedResearch pending

1121

AlcoholSubstance

Anxiety Mood Sleep

61% report better Mood

18 reports

Mostly negativeResearch pending

1260

Yerba MateSubstance

Energy Focus Mood

100% report better Mood

5 reports

Mostly positiveAResearch: Strong

1326

PsychedelicsSubstance

Mood Energy

100% report better Mood

5 reports

MixedAResearch: Strong

1425

Psilocybin MicrodosingSubstance

Mood Anxiety

100% report better Mood

5 reports

Mostly positiveCResearch: Limited

1521

Psilocybin MicrodoseSubstance

Mood Energy Anxiety

100% report better Mood

5 reports

Mostly positiveBResearch: Moderate

1634

Nicotine GumSubstance

Focus Energy Anxiety

86% report better Mood

7 reports

MixedAResearch: Strong

1728

TesofensineSubstance

Mood Energy Weight loss

100% report better Mood

4 reports

Mostly positiveBResearch: Moderate

1827

DmtSubstance

Mood

100% report better Mood

4 reports

Mostly positiveAResearch: Strong

1923

4-Aco-DmtSubstance

Mood Anxiety

100% report better Mood

4 reports

Mostly positiveDResearch: None

2014

DextromethorphanSubstance

Mood

100% report better Mood

4 reports

MixedAResearch: Strong

2143

Black TeaSubstance

Mood Energy Focus

100% report better Mood

3 reports

Mostly positiveAResearch: Strong

2241

TeaSubstance

Energy Anxiety Mood

100% report better Mood

3 reports

Mostly positiveResearch pending

2331

Methylene BlueSubstance

Energy Focus Mood

100% report better Mood

3 reports

Mostly positiveAResearch: Strong

2423

9-Me-BcSubstance

Mood Energy Focus

100% report better Mood

3 reports

MixedResearch pending

2523

MDMASubstance

Mood Anxiety Memory

47% report better Mood

15 reports

MixedAResearch: Strong

2642

AmphetaminesSubstance

Focus Energy Mood

75% report better Mood

4 reports

MixedAResearch: Strong

2743

Nicotine PatchSubstance

Focus Energy Memory

100% report better Mood

2 reports

Mostly positiveAResearch: Strong

2827

ShroomsSubstance

Mood Anxiety Sleep

100% report better Mood

2 reports

Mostly positiveDResearch: None

2924

TAK-653Substance

Focus Memory Mood

100% report better Mood

2 reports

Mostly positiveCResearch: Limited

3023

LSD MicrodosingSubstance

Focus Energy Mood

100% report better Mood

2 reports

MixedBResearch: Moderate

3123

MarijuanaSubstance

Sleep Focus Memory

100% report better Mood

2 reports

MixedAResearch: Strong

3221

AyahuascaSubstance

Mood

100% report better Mood

2 reports

MixedResearch pending

3321

Microdosing MushroomsSubstance

Mood Anxiety Energy

100% report better Mood

2 reports

Mostly positiveBResearch: Moderate

3420

MescalineSubstance

Mood

100% report better Mood

2 reports

Mostly positiveBResearch: Moderate

3514

4-FaSubstance

Mood Energy

100% report better Mood

2 reports

MixedResearch pending

3614

Nicotine VapeSubstance

Focus Mood

100% report better Mood

2 reports

MixedBResearch: Moderate

3714

Psilocybin MushroomSubstance

Mood Focus Energy

100% report better Mood

2 reports

MixedResearch pending

3835

Nicotine PatchesSubstance

Focus Mood

67% report better Mood

3 reports

Mostly positiveAResearch: Strong

3925

THCSubstance

Anxiety Sleep Memory

40% report better Mood

5 reports

MixedAResearch: Strong

4025

WeedSubstance

Anxiety Sleep Mood

50% report better Mood

2 reports

MixedAResearch: Strong

4119

CocaineSubstance

Focus Energy Mood

50% report better Mood

2 reports

Mostly negativeAResearch: Strong

4215

DxmSubstance

Mood Focus

50% report better Mood

2 reports

Mostly negativeAResearch: Strong

4312

MethamphetamineSubstance

Focus Mood

50% report better Mood

2 reports

Mostly negativeAResearch: Strong

447

Cannabis EdiblesSubstance

Mood Anxiety

50% report better Mood

2 reports

MixedBResearch: Moderate

Minimum 2 reports per entry. Information only — not medical advice. How rankings work