People mainly take LSD Microdose for mood, focus, anxiety. Based on 15 first-hand reports and 12 meta-analyses & systematic reviews in the medical literature. Ranked #264 of 1,974 overall.
Of reports that state an outcome, 80% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
At least one meta-analysis, or 5+ randomized controlled trials. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: Prim Care Companion CNS Disord 2024;26(1):23r03581. Author affiliations are listed at the end of this article.
PubMed 38228068 ↗Conclusion: Our review concludes that it is premature to draw any conclusions about the efficacy or safety of microdosing since the research quality cannot be considered confirmatory. We propose some potential causes for the current state of the literature and some suggestions for how these causes may be ameliorated.
PubMed 38374976 ↗Conclusion: However, better distinguishing between on-drug and off-drug effects is essential for clarifying whether microdosing exerts only transient pharmacological influences or promotes lasting cognitive change. Given the methodological heterogeneity across studies, future research using standardized protocols and mechanistic approaches is needed to fully characterize the cognitive and neural effects of microdosing classical psychedelics.
PubMed 41314362 ↗Conclusion: In this systematic review and meta-analysis of controlled clinical trials investigating PAT for depressive symptoms, a greater quantity of preparation therapy was associated with significantly larger reductions of depressive symptoms. These findings highlight a potential key role of preparation in optimizing PAT outcomes. The observed association primarily reflects quantitative aspects of therapy exposure rather than qualitative or process-related dimensions of the therapeutic interaction. Additional systematic research is needed to clarify this association and optimize all therapeutic compone
PubMed 41563753 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
Verbatim quotes, shortened only — each links to the original discussion.
“Microdoses are pretty much a cure for autism for me. If I'm on a microdose of LSD or mescaline, I have perfect days, utterly perfect.”
“LSD-Microdose: Seems to provoke healthy decisions in me. Helps overcoming conditioned behavior. Gives me some amount of energy and better concentration.”
“I microdose lsd when I'm going for a really long run on days off. I feel so happy... but I'm just running mile after mile.”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate