People mainly take MDMA for mood, anxiety, memory. Based on 38 first-hand reports and 99 meta-analyses & systematic reviews in the medical literature. Ranked #649 of 1,974 overall.
Of reports that state an outcome, 22% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: Nearly a third of the articles reported that no participants reported lasting adverse effects. Our analyses suggest that psychedelics reduce negative mood, and have potential efficacy in other mental disorders, such as substance-use disorders and PTSD.
PubMed 38574699 ↗Conclusion: Two medications, prazosin and risperidone, also have a small positive effect when used to augment pharmacological monotherapy. There was no evidence of superiority for one intervention over another in the small number of head-to-head comparison studies.
PubMed 34992738 ↗Conclusion: MDMA-AT demonstrates significant efficacy in improving PTSD symptoms, enhancing both response and remission rates in individuals with chronic, treatment-resistant PTSD, while maintaining a favorable safety profile.
PubMed 39381877 ↗Conclusion: Of the available psychedelic treatments for depressive symptoms, patients treated with high dose psilocybin showed better responses than those treated with placebo in the antidepressant trials, but the effect size was small.
PubMed 39168500 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
Verbatim quotes, shortened only — each links to the original discussion.
“How to biohack your intelligence with everything from sex to modafinil to MDMA”
“And if we ever feel lonely we can take MDMA with friends or boost our hormones and neurotransmitters.”
“Regularly using MDMA significantly reduces seretonin receptors for years, you should stop using it, it is very neurotoxic.”
“MDMA's well known pronounced effect on sociability, intimacy, and empathetic feelings”
“anecdotes of people exploiting this method to enhance their MDMA and recreational adderall high.”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate