People mainly take Cocaine for focus, energy, mood. Based on 28 first-hand reports and 500 meta-analyses & systematic reviews in the medical literature. Ranked #864 of 1,974 overall.
Of reports that state an outcome, 33% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: People with substance use disorders appear to have greater difficulties in emotion regulation than people without substance use disorders.
PubMed 35851975 ↗Conclusion: Contingency management and behavioral interventions along with pharmacotherapy should continue to be explored. Prospero CRD42018085667.
PubMed 31183685 ↗Conclusion: The effects of cocaine diminish with age and are largely mediated through psychosocial factors, whilst the relation between smoking and later delinquency is largely mediated by genetically inherited factors. Exposure to toxins during pregnancy may constitute an important but relatively unacknowledged cause of child psychiatric morbidity.
PubMed 17200791 ↗Conclusion: Evidence from trials and observational studies suggest that treatment retention is better for methadone than for sublingual buprenorphine. Comparative evidence on other outcomes examined showed few statistically significant differences and was generally based on small numbers of studies. These findings highlight the imperative for interventions to improve retention, consideration of client-centred factors (such as client preference) when selecting between methadone and buprenorphine, and harmonisation of data collection and reporting to strengthen future syntheses.
PubMed 37167985 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
Verbatim quotes, shortened only — each links to the original discussion.
“Cocaine is kind of similar just slightly more intense.”
“It destroys brain! Nothing else!”
“This is me but cocaine”
“Yeah, cocaine and heroin are a good start. The negative side effects will cancel each other out”
“Cocaine.”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate