People mainly take Psilocybin Microdose for mood, energy, anxiety. Based on 18 first-hand reports and 13 meta-analyses & systematic reviews in the medical literature. Ranked #798 of 1,974 overall.
Of reports that state an outcome, 61% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
At least one meta-analysis, or 5+ randomized controlled trials. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: Findings for other SUDs were mixed, though psilocybin showed potential in reducing opioid dependence and nicotine use. Preliminary evidence supports psilocybin's efficacy and safety for AUD and TUD, particularly with psychotherapy, but larger clinical trials are needed to confirm these findings.
PubMed 40245969 ↗Conclusion: Prim Care Companion CNS Disord 2024;26(1):23r03581. Author affiliations are listed at the end of this article.
PubMed 38228068 ↗Conclusion: Our review concludes that it is premature to draw any conclusions about the efficacy or safety of microdosing since the research quality cannot be considered confirmatory. We propose some potential causes for the current state of the literature and some suggestions for how these causes may be ameliorated.
PubMed 38374976 ↗Conclusion: However, better distinguishing between on-drug and off-drug effects is essential for clarifying whether microdosing exerts only transient pharmacological influences or promotes lasting cognitive change. Given the methodological heterogeneity across studies, future research using standardized protocols and mechanistic approaches is needed to fully characterize the cognitive and neural effects of microdosing classical psychedelics.
PubMed 41314362 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
Verbatim quotes, shortened only — each links to the original discussion.
“Micro dose shrooms are good if you can get it. This is the way. 0.3g makes for a fun night”
“I started to microdose psilocybin and after my very first dose I gave up vaping nicotine and drinking alcohol... zero desire to ever resume.”
“Microdosing psilocybin may be worth looking at.”
“3.2 grams is FAR more than a microdose. A microdose should be about 1/10 of a normal dose. When I microdose with psilocybin I take between 0.2 and 0.3 grams.”
“Curcumin Modafinil Sulbutiamine Psilocybin Microdose Phenibut”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate