Conclusion: Honey probably relieves cough symptoms to a greater extent than no treatment, diphenhydramine, and placebo, but may make little or no difference compared to dextromethorphan. Honey probably reduces cough duration better than placebo and salbutamol. There was no strong evidence for or against using honey. Most of the children received treatment for one night, which is a limitation to the results of this review. There was no difference in occurrence of adverse events between the honey and control arms.
PubMed 29633783 ↗Dextromethorphan
People mainly take Dextromethorphan for mood. Based on 8 first-hand reports and 62 meta-analyses & systematic reviews in the medical literature. Ranked #1091 of 1,974 overall.
Of reports that state an outcome, 32% are positive.
What Dextromethorphan does, according to users
Of the people who reported each effect, the share who said it got better.
3 more with fewer than 3 reports
What the research says
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: Since the last version of this review, we identified another study that added another form of medical therapy, BoNTs, specifically BoNT/A, to the list of pharmacologic interventions being reviewed for clinical efficacy in phantom limb pain. However, the results of this study did not substantially change the main conclusions. The short- and long-term effectiveness of BoNT/A, opioids, NMDA receptor antagonists, anticonvulsants, antidepressants, calcitonins, and local anaesthetics for clinically relevant outcomes including pain, function, mood, sleep, quality of life, treatment satisfaction, and
PubMed 27737513 ↗Conclusion: In this systematic review we present information relating to the effectiveness and safety of the following interventions: corticosteroids, capsaicin, dextromethorphan, dressings, gabapentin, herpes zoster vaccine, oral antiviral agents, oral opioid analgesics, lidocaine, topical antiviral agents (idoxuridine), and tricyclic antidepressants.
PubMed 21418680 ↗Conclusion: In this systematic review we present information relating to the effectiveness and safety of the following interventions: corticosteroids, dextromethorphan, dressings, gabapentin, oral antiviral agents, oral opioid analgesics, topical anaesthesia (lidocaine), topical antiviral agents (idoxuridine), topical counterirritants (capsaicin), tricyclic antidepressants.
PubMed 19454113 ↗Dosage people report
As stated by users — not a recommendation. Follow the label or your doctor.
Reported side effects
How often each side effect came up across all reports.
What users say
Verbatim quotes, shortened only — each links to the original discussion.
“So far, I'm aware of methylene blue, and also dextromethorphan.”
“ask about Wellbutrin, Auvelity (or adding dextromethorphan to Wellbutrin, which is what Auvelity is), ketamine, and TMS.”
“compounds like Ketamine or Dextromethorphan provide rather novel, effective, immediate and long-lasting anti-depressant qualities”
“I was prescribed bupropion and will occasionally take low doses of dxm because it seems to alleviate anxiety and really low feelings for the following couple of days.”
“dextromethorphan”
Top discussions (5)
- Sexual function has been fucked for 7 years at 27 years old. Trying to figure it out ↗
- Self-treatment of depression? ↗
- Novel antidepressant AXS-05 (dextromethorphan + bupropion), which demonstrated "rapid and substantial improvement of anhedonia," receives proposed labeling from the FDA. ↗
- Three sub-types of depression have been identified for the first time, new research reveals. One type does not respond to SSRI antidepressants, the most common treatment for depression. ↗
- AXS-05 (bupropion + dxm) Receives FDA Breakthrough Therapy Designation For Treatment Depression and Alzheimer's Disease Agitation ↗
Other options for mood
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate