People mainly take Tesofensine for mood, energy, weight loss. Based on 14 first-hand reports and 1 meta-analyses & systematic reviews in the medical literature. Ranked #459 of 1,974 overall.
Of reports that state an outcome, 63% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
At least one meta-analysis, or 5+ randomized controlled trials. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: TE produced a placebo-subtracted weight loss of approximately 4% for >14 weeks without any diet and lifestyle therapy, which is similar to that of sibutramine, but with no effect on blood pressure. On the basis of these results, TE is now being developed for obesity management.
PubMed 18356831 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
Verbatim quotes, shortened only — each links to the original discussion.
“I've been taking it for 3 days, 125ug the first two days and 250ug today... completely removed my symptoms of ADHD-PI and chronic dysthymia.”
“Tesofensine, I have found to help, along with other benefits.”
“I added the Teso (500mcg) beginning of May and my weight loss went from 1lb a week to 2lbs a week.”
“Look into these: Tirzepatide, Tesofensine, Tesamorelin/Ipamorelin OR CJC-1295 no dac/Ipamorelin, AOD9604.”
“Currently on tesofensine...Tirzepatide and tesofensine are great for appetite suppression”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate