People mainly take Methamphetamine for focus, mood. Based on 14 first-hand reports and 226 meta-analyses & systematic reviews in the medical literature. Ranked #1422 of 1,974 overall.
Of reports that state an outcome, 0% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: People with substance use disorders appear to have greater difficulties in emotion regulation than people without substance use disorders.
PubMed 35851975 ↗Conclusion: Prescription psychostimulants, particularly prescription amphetamines given in robust doses, have a clinically significant beneficial effect to promote abstinence in the treatment of individuals with PSUD, specifically the population with cocaine use disorder.
PubMed 32601988 ↗Conclusion: No pharmacotherapy yielded convincing results for the treatment of AMPH/MA dependence; mostly studies were underpowered and had low treatment completion rates. However, there were positive signals from several agents that warrant further investigation in larger scale studies; agonist therapies show promise. Common outcome measures should include change in use days. Future research must address the heterogeneity of AMPH/MA dependence (e.g. coexisting conditions, severity of disorder, differences between MA and AMPH dependence) and the role of psychosocial intervention.
PubMed 32185696 ↗Conclusion: Overall, NAC treatment appears to be safe and tolerable. Further well designed, larger controlled trials are needed for specific psychiatric and neurological disorders where the evidence is favorable.
PubMed 25957927 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
Verbatim quotes, shortened only — each links to the original discussion.
“chronic recreational doses of methamphetamine can cause excitotoxicity in humans”
“tren+meth+cialis+2cb and you will fuck a hole in the fabric of spacetime.”
“Energy, elated mood, talkativeness, confidence, fat burning ... strength, anything. Meth is the ultimate biohacking tool and nothing trumps”
“methamphet is mountains more neurotoxic than adderall. as far as i know, meth is possibly one of the most neurotoxic drugs i can think of”
“Rats that were injected only the Methamphetamine, without the NAC, showed a significant loss of dopamine concentrations in brain tissue, indicating neurotoxicity.”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate