People mainly take Methylene Blue for energy, focus, mood. Based on 46 first-hand reports and 131 meta-analyses & systematic reviews in the medical literature. Ranked #378 of 1,974 overall.
Of reports that state an outcome, 73% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: Among critically ill adults with septic shock, based on low-certainty evidence, MB may reduce short-term mortality, duration of vasopressors, and hospital length of stay, with no evidence of increased adverse events. Rigorous randomized trials evaluating the efficacy of MB in septic shock are needed.
PubMed 38904978 ↗Conclusion: The evidence supporting the use of hydroxocobalamin for shock is limited to anecdotal reports and a few cohort studies. Hydroxocobalamin appears to positively affect hemodynamics in shock, albeit similar to methylene blue.
PubMed 37147207 ↗Conclusion: This meta-analysis demonstrated that methylene blue administration was associated with an increased in mean arterial pressure and PaO2/FiO2 ratio, along with a reduction in mortality rates, serum lactate levels, and length of hospital stay. However, substantial degree of heterogeneity and inadequate number of studies with low level of evidence warrant future adequately powered RCTs to affirm our results.
PubMed 39615751 ↗Conclusion: This meta-analysis showed that MB reverses vasodilation in critically ill and perioperative patients and might improve survival. Further adequately powered randomized trials are needed to confirm these findings.
PubMed 37880041 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
Verbatim quotes, shortened only — each links to the original discussion.
“Methylene Blue (not cost effective)”
“So far, I'm aware of methylene blue, and also dextromethorphan.”
“Methlyene Blue. 0.5-5mg per day”
“Methylene Blue; has purported benefits in neurogenesis and other up-regulating factors”
“Methylene blue is a nice mitochondrial enhancer...For what it's worth, my mitochondria suck and I get a real kick out of methylene blue”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate