Cochrane Database Syst Rev · 2018 · Meta-analysis / systematic review
Nicotine replacement therapy versus control for smoking cessationConclusion: There is high-quality evidence that all of the licensed forms of NRT (gum, transdermal patch, nasal spray, inhalator and sublingual tablets/lozenges) can help people who make a quit attempt to increase their chances of successfully stopping smoking. NRTs increase the rate of quitting by 50% to 60%, regardless of setting, and further research is very unlikely to change our confidence in the estimate of the effect. The relative effectiveness of NRT appears to be largely independent of the intensity of additional support provided to the individual. Provision of more intense levels of support, alt
PubMed 29852054 ↗Cochrane Database Syst Rev · 2013 · Meta-analysis / systematic review
Pharmacological interventions for smoking cessation: an overview and network meta-analysisConclusion: NRT, bupropion, varenicline and cytisine have been shown to improve the chances of quitting. Combination NRT and varenicline are equally effective as quitting aids. Nortriptyline also improves the chances of quitting. On current evidence, none of the treatments appear to have an incidence of adverse events that would mitigate their use. Further research is warranted into the safety of varenicline and into cytisine's potential as an effective and affordable treatment, but not into the efficacy and safety of NRT.
PubMed 23728690 ↗Singapore Med J · 1993 · Meta-analysis / systematic review
Nicotine-replacement products in smoking cessation: a reviewConclusion: A review of recent clinical trials assessing the efficacy of the nicotine gum and the transdermal nicotine patch was conducted. Of the two products, the transdermal nicotine patch seems to have superior pharmacokinetics and fewer side-effects, and may well be the product of choice.
PubMed 8153711 ↗Cochrane Database Syst Rev · 2023 · Meta-analysis / systematic review
Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessationConclusion: There is high-certainty evidence that using combination NRT versus single-form NRT and 4 mg versus 2 mg nicotine gum can result in an increase in the chances of successfully stopping smoking. Due to imprecision, evidence was of moderate certainty for patch dose comparisons. There is some indication that the lower-dose nicotine patches and gum may be less effective than higher-dose products. Using a fast-acting form of NRT, such as gum or lozenge, resulted in similar quit rates to nicotine patches. There is moderate-certainty evidence that using NRT before quitting may improve quit rates versus
PubMed 37335995 ↗Indian J Med Res · 2018 · Meta-analysis / systematic review
Smokeless tobacco cessation interventions: A systematic reviewPubMed 30666002 ↗