4-Aco-Dmt
People mainly take 4-Aco-Dmt for mood, anxiety. Based on 9 first-hand reports and 0 meta-analyses & systematic reviews in the medical literature. Ranked #590 of 1,974 overall.
Of reports that state an outcome, 100% are positive.
What 4-Aco-Dmt does, according to users
Of the people who reported each effect, the share who said it got better.
What the research says
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
No randomized controlled trials in humans found on PubMed. The grade measures how much human research exists — read the conclusions below for what it found.
Dosage people report
As stated by users — not a recommendation. Follow the label or your doctor.
Reported side effects
How often each side effect came up across all reports.
What users say
Verbatim quotes, shortened only — each links to the original discussion.
“I can contribute my early 4 AcO DMT experiences to me being less depressed, happier and way more open minded person”
“one of the first insights that allowed me to break out of my own long-standing depression...came from my first trip on 4-AcO-DMT”
“I think microdosing 4-AcO-DMT would probably be very similar in effect to microdosing mushrooms, and it's much easier to get”
Other options for mood
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate