Best for mood

386 options people report for mood, motivation and low mood, ranked by the share of users who say it improved — weighted by how many reports there are.

Weight loss Appetite Focus Energy Sleep Anxiety Mood Memory Performance Recovery Pain & inflammation Digestion Libido Hormones Blood sugar Heart & lipids Skin & hair Immunity Longevity

Type:All Supplements Peptides Medications Substances Lifestyle Methods SARMs OtherResearch-backed only

56 results

141

TianeptineMedication

Mood Anxiety Focus

94% report better Mood

33 reports

MixedAResearch: Strong

236

KetamineMedication

Mood Anxiety Heart & lipids

97% report better Mood

29 reports

MixedAResearch: Strong

345

TestosteroneMedication

Performance Mood Libido

91% report better Mood

33 reports

Mostly positiveAResearch: Strong

438

BupropionMedication

Mood Energy Focus

81% report better Mood

27 reports

MixedAResearch: Strong

554

WellbutrinMedication

Mood Energy Focus

75% report better Mood

32 reports

MixedBResearch: Moderate

646

MemantineMedication

Mood Focus Anxiety

93% report better Mood

14 reports

MixedAResearch: Strong

746

ModafinilMedication

Focus Energy Mood

57% report better Mood

56 reports

MixedAResearch: Strong

836

LexaproMedication

Mood Anxiety Libido

100% report better Mood

9 reports

MixedBResearch: Moderate

970

TirzepatideMedication

Weight loss Appetite Mood

76% report better Mood

17 reports

Mostly positiveAResearch: Strong

1047

TRTMedication

Mood Energy Hormones

83% report better Mood

12 reports

Mostly positiveAResearch: Strong

1131

ZoloftMedication

Mood Anxiety Energy

83% report better Mood

12 reports

Mostly positiveBResearch: Moderate

1229

EscitalopramMedication

Mood Anxiety Energy

89% report better Mood

9 reports

MixedAResearch: Strong

1331

GabapentinMedication

Anxiety Sleep Mood

100% report better Mood

6 reports

MixedAResearch: Strong

1461

Testosterone Replacement TherapyMedication

Performance Energy Mood

75% report better Mood

12 reports

MixedAResearch: Strong

1534

AmphetamineMedication

Focus Energy Mood

80% report better Mood

10 reports

MixedAResearch: Strong

1628

FluoxetineMedication

Mood Anxiety Energy

69% report better Mood

13 reports

MixedAResearch: Strong

1762

TadalafilMedication

Libido Performance Mood

100% report better Mood

5 reports

Mostly positiveAResearch: Strong

1836

VyvanseMedication

Focus Mood Energy

48% report better Mood

31 reports

MixedBResearch: Moderate

1932

MethylphenidateMedication

Focus Mood Anxiety

56% report better Mood

18 reports

MixedAResearch: Strong

2024

VortioxetineMedication

Mood Memory Energy

100% report better Mood

4 reports

MixedAResearch: Strong

2153

AdderallMedication

Focus Mood Energy

39% report better Mood

54 reports

MixedAResearch: Strong

2243

SelegilineMedication

Mood Focus Energy

67% report better Mood

9 reports

MixedAResearch: Strong

2324

ProzacMedication

Mood Anxiety Libido

71% report better Mood

7 reports

MixedAResearch: Strong

2441

ArmodafinilMedication

Focus Energy Mood

80% report better Mood

5 reports

Mostly positiveAResearch: Strong

2557

CialisMedication

Libido Performance Heart & lipids

100% report better Mood

3 reports

Mostly positiveBResearch: Moderate

2641

Testosterone InjectionMedication

Mood Hormones Energy

100% report better Mood

3 reports

Mostly positiveBResearch: Moderate

2734

BaclofenMedication

Anxiety Mood Sleep

100% report better Mood

3 reports

Mostly positiveAResearch: Strong

2830

Testosterone Replacement Therapy (trt)Medication

Energy Mood Libido

100% report better Mood

3 reports

Mostly positiveAResearch: Strong

2919

Ketamine TherapyMedication

Mood Anxiety

100% report better Mood

3 reports

Mostly positiveBResearch: Moderate

3022

Intranasal InsulinMedication

Focus Memory Energy

75% report better Mood

4 reports

MixedAResearch: Strong

3119

LamotrigineMedication

Mood Anxiety Memory

75% report better Mood

4 reports

MixedAResearch: Strong

3259

Testosterone CypionateMedication

Performance Recovery Energy

100% report better Mood

2 reports

Mostly positiveBResearch: Moderate

3357

GuanfacineMedication

Focus Anxiety Sleep

100% report better Mood

2 reports

Mostly positiveAResearch: Strong

3435

IbuprofenMedication

Pain & inflammation Memory Focus

100% report better Mood

2 reports

MixedAResearch: Strong

3531

Low Dose NaltrexoneMedication

Focus Energy Mood

100% report better Mood

2 reports

Mostly positiveAResearch: Strong

3621

DextroamphetamineMedication

Focus Mood Energy

60% report better Mood

5 reports

MixedAResearch: Strong

3730

MirtazapineMedication

Sleep Mood Anxiety

67% report better Mood

3 reports

MixedAResearch: Strong

3829

RitalinMedication

Focus Mood Anxiety

36% report better Mood

11 reports

MixedAResearch: Strong

3933

EnclomipheneMedication

Hormones Libido Mood

43% report better Mood

7 reports

Mostly positiveBResearch: Moderate

409

Lithium CarbonateMedication

Mood Memory Energy

50% report better Mood

4 reports

MixedAResearch: Strong

4165

SemaglutideMedication

Weight loss Appetite Energy

40% report better Mood

5 reports

Mostly positiveAResearch: Strong

4225

Adderall XrMedication

Focus Mood Energy

40% report better Mood

5 reports

MixedBResearch: Moderate

4325

MetforminMedication

Performance Blood sugar Energy

50% report better Mood

2 reports

MixedAResearch: Strong

4422

BuspironeMedication

Anxiety Mood

50% report better Mood

2 reports

MixedAResearch: Strong

4521

PregabalinMedication

Anxiety Mood Memory

50% report better Mood

2 reports

MixedAResearch: Strong

4619

AcetaminophenMedication

Mood

50% report better Mood

2 reports

Mostly negativeAResearch: Strong

4715

AtomoxetineMedication

Focus Mood

50% report better Mood

2 reports

Mostly negativeAResearch: Strong

4814

DuloxetineMedication

Energy Mood

50% report better Mood

2 reports

MixedAResearch: Strong

4928

ClomidMedication

Hormones Mood Focus

25% report better Mood

4 reports

Mostly positiveBResearch: Moderate

5019

CitalopramMedication

Mood Libido

17% report better Mood

6 reports

Mostly negativeAResearch: Strong

5149

FinasterideMedication

Skin & hair Libido Mood

14% report better Mood

7 reports

MixedAResearch: Strong

5224

SertralineMedication

Anxiety Mood

0% report better Mood

4 reports

MixedAResearch: Strong

5355

TrazodoneMedication

Sleep Libido Mood

0% report better Mood

2 reports

MixedAResearch: Strong

5431

ConcertaMedication

Focus Energy Anxiety

0% report better Mood

2 reports

MixedBResearch: Moderate

5528

DexedrineMedication

Focus Energy Mood

0% report better Mood

2 reports

MixedBResearch: Moderate

5614

CymbaltaMedication

Mood Focus Energy

0% report better Mood

2 reports

Mostly negativeBResearch: Moderate

Minimum 2 reports per entry. Information only — not medical advice. How rankings work