People mainly take Testosterone Replacement Therapy (trt) for energy, mood, libido. Based on 6 first-hand reports and 43 meta-analyses & systematic reviews in the medical literature. Ranked #401 of 1,974 overall.
Of reports that state an outcome, 67% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: Also, further research is required before definitive conclusions on efficacy and safety can be made. This systematic review was registered at PROSPERO as CRD42020173623.
PubMed 33150931 ↗Conclusion: Intramuscular TRT is more effective than transdermal formulations at increasing LBM and improving muscle strength in middle-aged and older men, particularly in the lower extremities.
PubMed 29542875 ↗Conclusion: Despite a class effect of improving quality of life, depression, erectile function and libido, major improvements were not observed with the use of any individual product. We observed no statistically significant increase in the risk of adverse events; however, longer-term high-quality trials are needed to fully assess the risk of harm.
PubMed 29150464 ↗Conclusion: Until more definitive data becomes available, clinicians wishing to treat their hypogonadal patients with localized CaP with TRT should inform them of the lack of evidence regarding the safety of long-term treatment for the risk of CaP progression. However, in patients without known CaP, the evidence seems sufficient to think that androgen therapy does not increase the risk of subsequent discovery of CaP.
PubMed 32409202 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
Verbatim quotes, shortened only — each links to the original discussion.
“I am not having anymore kids, and have done TRT for 10 years. I was just curious so thought i would check. Yep TRT is a form of birth control.”
“As someone who's been on TRT for more than 2 years, I can tell you I've never felt calmer in my life. / unnecessary testosterone treatment can be associated with a host of health problems: cardiac risk from heart muscle ”
“I went on TRT two years ago because my test levels were at 270...got my levels up to 700 and lost 8 lbs...reducing my TRT to 40 mg/week...looking to get ripped.”
“I was put on trt 200mg/week and my life changed before my eyes. I was 233 testosterone at 29. I'm now into peptides like BPC and tb500”
“TRT is still the gold standard for hypogonadism”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate