Conclusion: The three drugs with the highest OR value in response were NASID (OR = 3.62(1.58, 8.32)), venlafaxin (OR = 3.50(1.83, 6.70)) and ketamine (OR = 3.28(1.89, 5.68)), while the highest OR value in remission were NASID (OR = 3.17(1.60, 6.29)), ketamine (OR = 2.99(1.58, 5.67)) and venlafaxin (OR = 2.55(1.72, 3.78)). Through reading the literature, we found 69 SNPs associated with depression. Major depression was a debilitating disorder that could ultimately lead to enormous societal and economical challenge [1]. The number of person which affected by depression was up to 16% of the population worldw
PubMed 33099342 ↗Prozac
People mainly take Prozac for mood, anxiety, libido. Based on 20 first-hand reports and 5 meta-analyses & systematic reviews in the medical literature. Ranked #581 of 1,974 overall.
Of reports that state an outcome, 27% are positive.
What Prozac does, according to users
Of the people who reported each effect, the share who said it got better.
5 more with fewer than 3 reports
What the research says
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: As predicted, both clinician and patient outcome ratings correlated significantly with the percentage of patients experiencing side effects. Questions are raised about the role of side effects in mediating drug outcome results.
PubMed 7931201 ↗Conclusion: Our purpose is to provide an overview of the potential pharmacotherapies or compounds tested in established rodent models of binge eating behavior. These findings will help provide guidance for determining pharmacological effectiveness for potential novel or repurposed pharmacotherapies.
PubMed 37238615 ↗Conclusion: This systematic review highlighted that there are differences between fluoxetine and specific comparator antidepressants. Several of the differences met a prespecified criterion for clinical significance. The statistical approach adopted in this systematic review could represent a useful tool for putting clinical trial data into practice.
PubMed 16848644 ↗Dosage people report
As stated by users — not a recommendation. Follow the label or your doctor.
Reported side effects
How often each side effect came up across all reports.
What users say
Verbatim quotes, shortened only — each links to the original discussion.
“SSRI (Prozac) was amazing for me while I was a teen. No longer need it but I went from wanting to kill myself every second of the day to feeling tolerable.”
“I’ve been on Prozac myself and suicidal 20 years ago but 47 and ok now.”
“20mg or Prozac and 50 mg twice a day for my depression, anxiety, and mood swings. It works.”
“Prozac : Tired, weird, not for me”
“lots of prescription anti-depressants such as prozac, citalopram, seroxat, mirtazapine. The only one that really helped me was mirtazapine”
Top discussions (5)
- Magnesium. Was it really That simple this WHOLE TIME!?!? ↗
- In a study of young men (average age of 27) experiencing Post-SSRI Sexual Dysfunction, the average erectile function score was consistent with severe ED. Ultrasound findings indicated that the penile tissue of these young men resembled that of men in their mid-60s. ↗
- People who want to start taking SSRIs or other antidepressants must be aware of this!! ↗
- Do any of you think we’re just spinning in circles? ↗
- Why do MDMA and SSRIs have completely different effects, if both increase extracellular serotonin? ↗
Other options for mood
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate