PlainPill

Prozac

People mainly take Prozac for mood, anxiety, libido. Based on 20 first-hand reports and 5 meta-analyses & systematic reviews in the medical literature. Ranked #581 of 1,974 overall.

24
User score
Mixed
20% positive25% mixed30% negative25% unclear

Of reports that state an outcome, 27% are positive.

Clinical research
AStrong research base
5
meta-analyses
20
RCTs
507
papers

What Prozac does, according to users

Of the people who reported each effect, the share who said it got better.

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

AStrong research base

3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.

J Clin Neurosci · 2020 · Meta-analysis / systematic review
Application of antidepressants in depression: A systematic review and meta-analysis

Conclusion: The three drugs with the highest OR value in response were NASID (OR = 3.62(1.58, 8.32)), venlafaxin (OR = 3.50(1.83, 6.70)) and ketamine (OR = 3.28(1.89, 5.68)), while the highest OR value in remission were NASID (OR = 3.17(1.60, 6.29)), ketamine (OR = 2.99(1.58, 5.67)) and venlafaxin (OR = 2.55(1.72, 3.78)). Through reading the literature, we found 69 SNPs associated with depression. Major depression was a debilitating disorder that could ultimately lead to enormous societal and economical challenge [1]. The number of person which affected by depression was up to 16% of the population worldw

PubMed 33099342 ↗
J Clin Psychiatry · 2006 · Meta-analysis / systematic review
Are all antidepressants really the same? The case of fluoxetine: a systematic review

Conclusion: This systematic review highlighted that there are differences between fluoxetine and specific comparator antidepressants. Several of the differences met a prespecified criterion for clinical significance. The statistical approach adopted in this systematic review could represent a useful tool for putting clinical trial data into practice.

PubMed 16848644 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

20 mgas reported
low doseas reported
40 mgdaily
dailyas reported
microdoseas reported

Reported side effects

How often each side effect came up across all reports.

pssd ×1ed ×1libido loss ×1fatigue ×1low libido ×1erectile dysfunction ×1suicidal thoughts ×1

What users say

Verbatim quotes, shortened only — each links to the original discussion.

“SSRI (Prozac) was amazing for me while I was a teen. No longer need it but I went from wanting to kill myself every second of the day to feeling tolerable.”
Source discussion ↗
“I’ve been on Prozac myself and suicidal 20 years ago but 47 and ok now.”
Source discussion ↗
“20mg or Prozac and 50 mg twice a day for my depression, anxiety, and mood swings. It works.”
Source discussion ↗
“Prozac : Tired, weird, not for me”
Source discussion ↗
“lots of prescription anti-depressants such as prozac, citalopram, seroxat, mirtazapine. The only one that really helped me was mirtazapine”
Source discussion ↗
Top discussions (5)

Other options for mood

User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate