People mainly take Semaglutide for weight loss, appetite, energy. Based on 137 first-hand reports and 421 meta-analyses & systematic reviews in the medical literature. Ranked #8 of 1,974 overall.
Of reports that state an outcome, 69% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: This study shows that new anti-diabetic drugs, particularly GLP1-RA and Tirzepatide, are the most effective in inducing weight loss in patients with type 2 diabetes. Interestingly, exenatide appears to be the only GLP1-RA that induces a mild weight loss.
PubMed 34302978 ↗Conclusion: Among individuals with obesity without type 2 diabetes, subcutaneous semaglutide is effective for weight loss with an 11.85% reduction from baseline compared to placebo. This supports the use of semaglutide for weight management in obesity. However, risk of gastrointestinal adverse events, discontinuation of treatment and serious adverse events were higher in the semaglutide group versus placebo.
PubMed 36578889 ↗Conclusion: Potent GLP-1 RAs, such as tirzepatide and semaglutide, demonstrate greater overall weight loss but are associated with a significant reduction in lean mass.
PubMed 39719170 ↗Conclusion: The proportion of weight regained was proportional to the amount originally lost. Meaning: Discontinuation of GLP-1RA treatment leads to weight regain, regardless of lifestyle interventions, and should therefore be considered a chronic therapy to prevent weight regain and associated undesirable outcomes related to obesity.
PubMed 40186344 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
Verbatim quotes, shortened only — each links to the original discussion.
“I've been inconstent with all 3, and I haven't seen much weight loss.”
“the only anti-aging drug I take is rapamycin and semaglutide, both of which blow metformin out of the water.”
“Semaglutide!... Not a supplement but Semaglutide and Tirzapetide are showing great promise in this area.”
“My wife has Sema,selenk, Semax”
“I started on semaglutide for 2 months very little weight loss like 10@15 loss”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate