Zoloft
People mainly take Zoloft for mood, anxiety, energy. Based on 20 first-hand reports and 0 meta-analyses & systematic reviews in the medical literature. Ranked #388 of 1,974 overall.
Of reports that state an outcome, 64% are positive.
What Zoloft does, according to users
Of the people who reported each effect, the share who said it got better.
5 more with fewer than 3 reports
What the research says
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
At least one meta-analysis, or 5+ randomized controlled trials. The grade measures how much human research exists — read the conclusions below for what it found.
Dosage people report
As stated by users — not a recommendation. Follow the label or your doctor.
Reported side effects
How often each side effect came up across all reports.
What users say
Verbatim quotes, shortened only — each links to the original discussion.
“I am on Zoloft to treat IBS. I have also been put on 4 other SSRIs which had more side effects.”
“got on Zoloft, and it changed my life”
“Zoloft allowed me to enjoy my child’s first year of life instead of living in fear. It allowed me to pick up a hobby and switch jobs and not be afraid of any of it.”
“Zoloft 50mg”
“also prescribed/on zoloft and klonopin”
Top discussions (5)
- People who want to start taking SSRIs or other antidepressants must be aware of this!! ↗
- My story of Premature ejaculation, a plea for help. ↗
- Trying to avoid Zoloft - how’s this? ↗
- 1+ year of therapy, nothing works. Took 60 mg memantine today. My last hope ↗
- Anxiety/Anhedonia/Dysthymia/Brain-Fog... Summary of what actually worked for me personally ↗
Other options for mood
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate