PlainPill

Dextroamphetamine

People mainly take Dextroamphetamine for focus, mood, energy. Based on 20 first-hand reports and 48 meta-analyses & systematic reviews in the medical literature. Ranked #777 of 1,974 overall.

21
User score
Mixed
15% positive40% mixed5% negative40% unclear

Of reports that state an outcome, 25% are positive.

Clinical research
AStrong research base
48
meta-analyses
119
RCTs
867
papers

What Dextroamphetamine does, according to users

Of the people who reported each effect, the share who said it got better.

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

AStrong research base

3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.

PLoS One · 2020 · Meta-analysis / systematic review
Pharmacologic treatment of attention deficit hyperactivity disorder in adults: A systematic review and network meta-analysis

Conclusion: Overall, despite a class effect of improving clinical response relative to placebo, there were few differences among the individual ADHD pharmacotherapies, and most studies were at risk of at least one important source of bias. Furthermore, the certainty of the evidence was very low to low for all outcomes, and there was limited reporting of long-term adverse events. As such, the choice between ADHD pharmacotherapies may depend on individual patient considerations, and future studies should assess the long-term effects of individual pharmacotherapies on patient-important outcomes, including qu

PubMed 33085721 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

prescribeddaily
1.25-2.5 mgmicrodose
4 times/weekas reported
10-15 mgdaily

Reported side effects

How often each side effect came up across all reports.

brain fog ×1jaw clenching ×1fatigue ×1heart racing ×1nervousness ×1insomnia ×1erectile dysfunction ×1

What users say

Verbatim quotes, shortened only — each links to the original discussion.

“I've tried Dextroamphetamine before (off brand) and get a little too far up the tree, rather enjoyably of course, then crashed to shit. Depression, back pain, jaw clenching, and mindfog.”
Source discussion ↗
“I take dextroamphetamine (prescribed) daily and am suffering from pretty bad depression”
Source discussion ↗
“straight d-amp is my favorite for motivation”
Source discussion ↗
“Why is dextroamphetamine so effective in the first 2 hours and then useless for the next 10 hours despite still being in your system?”
Source discussion ↗
“There's pure dextroamphetamine that you could try or reuptake inhibitors like Ritalin could help.”
Source discussion ↗
Top discussions (5)

Other options for focus

User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate