Conclusion: Overall, despite a class effect of improving clinical response relative to placebo, there were few differences among the individual ADHD pharmacotherapies, and most studies were at risk of at least one important source of bias. Furthermore, the certainty of the evidence was very low to low for all outcomes, and there was limited reporting of long-term adverse events. As such, the choice between ADHD pharmacotherapies may depend on individual patient considerations, and future studies should assess the long-term effects of individual pharmacotherapies on patient-important outcomes, including qu
PubMed 33085721 ↗Dextroamphetamine
People mainly take Dextroamphetamine for focus, mood, energy. Based on 20 first-hand reports and 48 meta-analyses & systematic reviews in the medical literature. Ranked #777 of 1,974 overall.
Of reports that state an outcome, 25% are positive.
What Dextroamphetamine does, according to users
Of the people who reported each effect, the share who said it got better.
4 more with fewer than 3 reports
What the research says
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: Prescription psychostimulants, particularly prescription amphetamines given in robust doses, have a clinically significant beneficial effect to promote abstinence in the treatment of individuals with PSUD, specifically the population with cocaine use disorder.
PubMed 32601988 ↗Conclusion: J Clin Sleep Med. 2021;17(9):1895-1945.
PubMed 34743790 ↗Conclusion: Exercise and psychological interventions are effective for reducing CRF during and after cancer treatment, and they are significantly better than the available pharmaceutical options. Clinicians should prescribe exercise or psychological interventions as first-line treatments for CRF.
PubMed 28253393 ↗Dosage people report
As stated by users — not a recommendation. Follow the label or your doctor.
Reported side effects
How often each side effect came up across all reports.
What users say
Verbatim quotes, shortened only — each links to the original discussion.
“I've tried Dextroamphetamine before (off brand) and get a little too far up the tree, rather enjoyably of course, then crashed to shit. Depression, back pain, jaw clenching, and mindfog.”
“I take dextroamphetamine (prescribed) daily and am suffering from pretty bad depression”
“straight d-amp is my favorite for motivation”
“Why is dextroamphetamine so effective in the first 2 hours and then useless for the next 10 hours despite still being in your system?”
“There's pure dextroamphetamine that you could try or reuptake inhibitors like Ritalin could help.”
Top discussions (5)
- L-theanine and Caffeine Improve Sustained Attention, Impulsivity and Cognition in Children with Attention Deficit Hyperactivity Disorders by Decreasing Mind Wandering - PUBMED 2019. ↗
- Saffron is the most adderall-like nootropic I've found ↗
- Blue Lotus in Coffee Cuts Stimulant Anxiety More Effectively Than L-theanine ↗
- Why is dextroamphetamine so effective in the first 2 hours and then useless for the next 10 hours despite still being in your system? ↗
- Substitute to Adderall ↗
Other options for focus
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate