PlainPill

TRT

People mainly take TRT for mood, energy, hormones. Based on 101 first-hand reports and 96 meta-analyses & systematic reviews in the medical literature. Ranked #145 of 1,974 overall.

47
User score
Mostly positive
32% positive11% mixed2% negative55% unclear

Of reports that state an outcome, 71% are positive.

Clinical research
AStrong research base
96
meta-analyses
195
RCTs
3,011
papers

What TRT does, according to users

Of the people who reported each effect, the share who said it got better.

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

AStrong research base

3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.

Sports Med · 2022 · Meta-analysis / systematic review
Comparison of Weightlifting, Traditional Resistance Training and Plyometrics on Strength, Power and Speed: A Systematic Review with Meta-Analysis

Conclusion: Overall, these findings support the notion that if the training goal is to improve strength, power and speed, supplementary weightlifting training may be advantageous for athletic development. Whilst WLT and PLYO may result in similar improvements, WLT can elicit additional benefits above that of TRT, resulting in greater improvements in weightlifting and jumping performance.

PubMed 35025093 ↗
Cochrane Database Syst Rev · 2020 · Meta-analysis / systematic review
Cognitive behavioural therapy for tinnitus

Conclusion: CBT may be effective in reducing the negative impact that tinnitus can have on quality of life. There is, however, an absence of evidence at 6 or 12 months follow-up. There is also some evidence that adverse effects may be rare in adults with tinnitus receiving CBT, but this could be further investigated. CBT for tinnitus may have small additional benefit in reducing symptoms of depression although uncertainty remains due to concerns about the quality of the evidence. Overall, there is limited evidence for CBT for tinnitus improving anxiety, health-related quality of life or negatively biased

PubMed 31912887 ↗
Cochrane Database Syst Rev · 2017 · Meta-analysis / systematic review
Gabapentin for chronic neuropathic pain in adults

Conclusion: Gabapentin at doses of 1800 mg to 3600 mg daily (1200 mg to 3600 mg gabapentin encarbil) can provide good levels of pain relief to some people with postherpetic neuralgia and peripheral diabetic neuropathy. Evidence for other types of neuropathic pain is very limited. The outcome of at least 50% pain intensity reduction is regarded as a useful outcome of treatment by patients, and the achievement of this degree of pain relief is associated with important beneficial effects on sleep interference, fatigue, and depression, as well as quality of life, function, and work. Around 3 or 4 out of 10 pa

PubMed 28597471 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

200 mgregular intervals
generous doseas reported
2 yearsas reported
0.8 ml (160 mg)2x/week
4 yearsas reported
300 mgweekly

Reported side effects

How often each side effect came up across all reports.

suppression ×2fertility issues ×1testicular shrinkage ×1polycythemia ×1fatigue ×1water retention ×1natural testosterone ×1

What users say

Verbatim quotes, shortened only — each links to the original discussion.

“If your T is that low I would suggest all of the above along with TRT. No herbal supplement is going to fix that.”
Source discussion ↗
“I wish my country was cooler about trt. I really want to get on it when I hit 30.”
Source discussion ↗
“TRT, on the other hand, has been a dramatic game changer.”
Source discussion ↗
“I'm trying the obvious things: on TRT, taking creatine, injecting L-Carnitine, multivitamins.”
Source discussion ↗
“I feel much better now and am chasing the wife around the house lol!”
Source discussion ↗
Top discussions (5)

Other options for mood

User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate