PlainPill

Lexapro

People mainly take Lexapro for mood, anxiety, libido. Based on 25 first-hand reports and 1 meta-analyses & systematic reviews in the medical literature. Ranked #278 of 1,974 overall.

36
User score
Mixed
40% positive16% mixed16% negative28% unclear

Of reports that state an outcome, 56% are positive.

Clinical research
BModerate research base
1
meta-analyses
4
RCTs
51
papers

What Lexapro does, according to users

Of the people who reported each effect, the share who said it got better.

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

BModerate research base

At least one meta-analysis, or 5+ randomized controlled trials. The grade measures how much human research exists — read the conclusions below for what it found.

J Womens Health (Larchmt) · 2019 · Meta-analysis / systematic review
Selective Serotonin Reuptake Inhibitors and Persistent Pulmonary Hypertension of the Newborn: An Update Meta-Analysis

Conclusion: Current evidence suggests that there were significantly greater odds of PPHN with SSRI use during pregnancy. However, the clinical significance of this association remains modest and likely outweighed by the potential benefits of treatment of perinatal depression. The risk of PPHN associated with SSRI therapy might not warrant the recommendation to withdraw antidepressant therapy, as evidence from other studies show that untreated perinatal depression presents additional adverse maternal and fetal outcomes. Given the increasing prevalence of maternal depression and consequent use of antidepres

PubMed 30407100 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

less than 1 mgdaily
10 mgdaily
5 mgdaily
15 mgas reported
dailyas reported

Reported side effects

How often each side effect came up across all reports.

brain fog ×2withdrawal ×2fatigue ×1pssd ×1anhedonia ×1emotional blunting ×1cognitive decline ×1difficulty achieving ×1

What users say

Verbatim quotes, shortened only — each links to the original discussion.

“Lexapro didn't really help me at all, made me more lethargic and gave me way more brain fog if anything”
Source discussion ↗
“Topiramate, Stablon, Lexapro, Quetiapin, Clonazepam”
Source discussion ↗
“I'm on lexapro”
Source discussion ↗
“After over a year of trying several different non-SSRI anxiety and depression medications, getting on escitalopram (lexapro) has had undeniable positive effects on me”
Source discussion ↗
“I haven't always felt like this so I wanted to explore more options before starting that. He then tested for Lyme and testosterone. He wanted to start Lexapro. I haven't always felt like this so I wanted to explore more ”
Source discussion ↗
Top discussions (5)

Other options for mood

User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate