People mainly take Testosterone Replacement Therapy for performance, energy, mood. Based on 43 first-hand reports and 72 meta-analyses & systematic reviews in the medical literature. Ranked #21 of 1,974 overall.
Of reports that state an outcome, 57% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: Although complications of AAS use are variable and patient specific, they can be successfully managed. Treatment of ASIH depends on the type and duration of AAS use. Specific details regarding a patient's AAS cycle are important in medical management.
PubMed 24636400 ↗Conclusion: Although studies directly comparing the safety of SC vs IM administration of testosterone esters are desirable, clinicians should consider discussing the SC route with their patients because it is easier to self-administer and has the potential to improve patient adherence.
PubMed 34698352 ↗Conclusion: Whereas the incidence of non-fatal arrhythmias and AF was increased in the only trial considering CV safety as the primary endpoint, this was not confirmed when all other studies were considered (MH-OR 1.61[0.84;3.08] and 1.44[0.46;4.46]). Similarly, no relationship between endogenous T levels and AF incidence was observed after the adjustment for confounders Available data confirm that TRT is safe and it is not related to an increased CV risk.
PubMed 38553429 ↗Conclusion: Intramuscular TRT is more effective than transdermal formulations at increasing LBM and improving muscle strength in middle-aged and older men, particularly in the lower extremities.
PubMed 29542875 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
Verbatim quotes, shortened only — each links to the original discussion.
“I had the same levels as mentioned above before I started TRT and now I’m at around 900 ng/dL... now I am experiencing new side effects”
“TRT / Testosterone replacement - $40 / month”
“all roads lead to TRT... If you don't want to use needles, cream works just as well or better.”
“and TRT, along with an intense diet”
“the only two 'supplements' I've used are tirz & trt...I lift 3-5x a week”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate