People mainly take Low Dose Naltrexone for focus, energy, mood. Based on 21 first-hand reports and 14 meta-analyses & systematic reviews in the medical literature. Ranked #377 of 1,974 overall.
Of reports that state an outcome, 87% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: These effects appear to unique at low dosage compared to dosage for food and drug administration approved use for alcohol and opioid dependence. We review the evidence that LDN has shown more than promise and should be further investigated in clinical practice.
PubMed 32845365 ↗Conclusion: LDN is better than placebo in fibromyalgia pain management, and LDN is similar to active controls in chronic pain management.
PubMed 40540205 ↗Conclusion: Although LDN marginally reduced pain and symptom severity from baseline, these effects were not superior to placebo. This suggests that LDN may not provide significant clinical benefit over placebo in fibromyalgia management, warranting further research.
PubMed 40272382 ↗Conclusion: There is insufficient evidence to evaluate the effectiveness of sustained-release naltrexone for treatment of opioid dependence. For naltrexone injections, administration site-related adverse effects appear to be frequent, but of moderate intensity and time limited. For a harm-benefit evaluation of naltrexone implants, more data on side effects and adverse events are needed.
PubMed 18425938 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
Verbatim quotes, shortened only — each links to the original discussion.
“will go for Low Dose Naltrexone because it's fking awesome, and legal prescritpted.”
“I’m on a lot of other stuff. Ketamine, low dose naltrexone, etc.”
“It helped me defeat Graves disease and it's used for all sorts of immune related diseases. However one known side benefit is that it gives you extremely deep and healthy sleep”
“I started takin low dose naltrexone for my autoimmune disorder. But the biggest change I've had has been with my anxiety. It took a couple months but it has been a complete turn around.”
“Try low-dose naltrexone. Some people with long Covid are having success with that.”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate