Semaglutide vs Tirzepatide for weight loss
Short answer: For weight loss, more users report improvement with Tirzepatide — 93% of 195 reports, versus 84% of 129 for Semaglutide.
Semaglutide has 421 meta-analyses and 307 randomized trials on PubMed; Tirzepatide has 214 and 132.
Based on 314 reports about Semaglutide and 408 about Tirzepatide. Not medical advice.
| Semaglutide Medication | Tirzepatide Medication | |
|---|---|---|
| User score | 64 | 68 |
| Verdict | Mostly positive | Mostly positive |
| Positive of reports that state an outcome | 64% | 76% |
| Reports | 314 | 408 |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 421 / 307 | 214 / 132 |
| Mainly used for | ||
| Weight loss % reporting improvement | 84% (129) | 93% (195) |
| Appetite % reporting improvement | 83% (64) | 86% (71) |
| Focus % reporting improvement | 60% (5) | 67% (3) |
| Energy % reporting improvement | 39% (23) | 45% (31) |
| Sleep % reporting improvement | 50% (4) | 56% (9) |
| Mood % reporting improvement | 27% (11) | 68% (25) |
| Performance % reporting improvement | 83% (6) | 83% (12) |
| Recovery % reporting improvement | 100% (2) | — |
| Pain & inflammation % reporting improvement | 80% (5) | 86% (7) |
| Digestion % reporting improvement | 43% (7) | 20% (5) |
| Libido % reporting improvement | 0% (3) | 33% (6) |
| Hormones % reporting improvement | 100% (2) | 50% (2) |
| Blood sugar % reporting improvement | 88% (8) | 80% (10) |
| Heart & lipids % reporting improvement | 100% (3) | 88% (8) |
| Skin & hair % reporting improvement | 33% (3) | 0% (2) |
| Common side effects | nausea, fatigue, stomach issues, constipation | fatigue, nausea, constipation, stomach issues |
| Typical dose reported | 2.4 mg / once weekly | 7.5 mg |
This study shows that new anti-diabetic drugs, particularly GLP1-RA and Tirzepatide, are the most effective in inducing weight loss in patients with type 2 diabetes. Interestingly, exenatide appears to be the only GLP1-RA that induces a mild weight loss.
Pharmacol Res, 2021 ↗“I've lost 35lbs since then and now I'm in the Healthy range on BMI. My IBSD has virtually disappeared.”
This study shows that new anti-diabetic drugs, particularly GLP1-RA and Tirzepatide, are the most effective in inducing weight loss in patients with type 2 diabetes. Interestingly, exenatide appears to be the only GLP1-RA that induces a mild weight loss.
Pharmacol Res, 2021 ↗“Tirzepatide works so well! Do some research in the r/peptides subreddit and the r/tirzepatide subreddit. It's the most effective thing I've ever seen for appetite suppressant.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate