Creatine vs Semaglutide for blood sugar
Short answer: For blood sugar, more users report improvement with Creatine — 100% of 5 reports, versus 90% of 10 for Semaglutide.
Creatine has 763 meta-analyses and 2,794 randomized trials on PubMed; Semaglutide has 421 and 307.
Based on 2,279 reports about Creatine and 330 about Semaglutide. Not medical advice.
| Creatine Supplement | Semaglutide Medication | |
|---|---|---|
| Users say it helped | 72%helped1,048 reports · high confidence | 64%helped228 reports · high confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 763 / 2,794 | 421 / 307 |
| Mainly used for | ||
| Performance % reporting improvement | 98% (542) | 83% (6) |
| Energy % reporting improvement | 97% (268) | 39% (23) |
| Focus % reporting improvement | 93% (249) | 60% (5) |
| Weight loss % reporting improvement | 77% (31) | 85% (138) |
| Mood % reporting improvement | 87% (125) | 27% (11) |
| Common side effects | stomach issues, hair loss, insomnia, water retention | nausea, fatigue, stomach issues, constipation |
| Typical dose reported | 5 g / daily | Not listed |
The results of the meta-analysis suggest that creatine supplementation did not significantly alter serum creatinine levels (standardized mean difference = 0.48, 95% confidence interval 0.24-0.73, P = .001, I2 = 22%), and did not alter plasma urea values (standardized mean difference = 1.10, 95% confidence interval 0.34-1.85, P = .004, I2 = 28%). The findings indicate that creatine supplementation does not induce renal damage in the studied amounts and durations.
J Ren Nutr, 2019 ↗“I actually feel a lot better. Mentally clearer and more balanced, like I have my brain back.”
This study shows that new anti-diabetic drugs, particularly GLP1-RA and Tirzepatide, are the most effective in inducing weight loss in patients with type 2 diabetes. Interestingly, exenatide appears to be the only GLP1-RA that induces a mild weight loss.
Pharmacol Res, 2021 ↗“I've lost 35lbs since then and now I'm in the Healthy range on BMI. My IBSD has virtually disappeared.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate