What are the side effects of Semaglutide?

Users most often report nausea, fatigue, stomach issues, constipation, vomiting. Side effects came up 94 times across 330 reports.

User reports can't establish safety. PubMed lists 421 meta-analyses and 307 randomized trials. Talk to a doctor or pharmacist, especially if you take other medication.

Semaglutide side effects

Across 330 first-hand reports, people mentioned a side effect 94 times (about 28 per 100 reports). The most common: nausea, fatigue, stomach issues. User reports show what people notice — they can't tell you whether Semaglutide is safe for you.

Reported side effects

nausea35

fatigue20

stomach issues11

constipation9

vomiting6

anhedonia5

headache5

depression3

What got worse for some people

Energy61% worse · 39% better · of 23 Mood73% worse · 27% better · of 11 Weight loss4% worse · 85% better · of 138 Appetite7% worse · 80% better · of 70 Digestion57% worse · 43% better · of 7

In their own words

“I tried ozempic at first. Made me really sick so I stopped.”

Didn't helpRead the discussion ↗

“I recently cycled off Ozempic after 6 months. It did not agree with me...profund depression...profound depression(something I dont normally have an issue with).”

MixedRead the discussion ↗

“I’ve noticed since getting on the wegovy I have felt like I’ve been in a strange depression. I’m not explicitly suicidal but I feel nothing - no happiness, no love, no hope.”

MixedRead the discussion ↗

“Started working right away. First day I didn't eat for 8 hours and I only did because I knew I needed to.”

HelpedRead the discussion ↗

“I was thicker than you, but not obese... Worked great as a cutting agent.”

HelpedRead the discussion ↗

“With semaglutide, my side effects were fatigue, depression, and very mild nausea.”

MixedRead the discussion ↗

Is Semaglutide safe? What the research covers

AResearch: Strong421 meta-analyses · 307 randomized trials on PubMed

J ASEAN Fed Endocr Soc · 2022

Efficacy and Safety of Semaglutide for Weight Loss in Obesity Without Diabetes: A Systematic Review and Meta-Analysis

Conclusion: Among individuals with obesity without type 2 diabetes, subcutaneous semaglutide is effective for weight loss with an 11.85% reduction from baseline compared to placebo. This supports the use of semaglutide for weight management in obesity. However, risk of gastrointestinal adverse events, discontinuation of treatment and serious adverse events were higher in the semaglutide group versus placebo.