Berberine vs Semaglutide for appetite
Short answer: For appetite, users rate them about the same: 87% report improvement with Berberine (15 reports) and 83% with Semaglutide (64 reports).
Berberine has 109 meta-analyses and 110 randomized trials on PubMed; Semaglutide has 421 and 307.
Based on 294 reports about Berberine and 314 about Semaglutide. Not medical advice.
| Berberine Supplement | Semaglutide Medication | |
|---|---|---|
| User score | 47 | 64 |
| Verdict | Mixed | Mostly positive |
| Positive of reports that state an outcome | 56% | 64% |
| Reports | 294 | 314 |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 109 / 110 | 421 / 307 |
| Mainly used for | ||
| Weight loss % reporting improvement | 84% (19) | 84% (129) |
| Appetite % reporting improvement | 87% (15) | 83% (64) |
| Focus % reporting improvement | 33% (6) | 60% (5) |
| Energy % reporting improvement | 90% (21) | 39% (23) |
| Sleep % reporting improvement | 75% (4) | 50% (4) |
| Anxiety % reporting improvement | 50% (8) | — |
| Mood % reporting improvement | 86% (14) | 27% (11) |
| Performance % reporting improvement | 67% (3) | 83% (6) |
| Recovery % reporting improvement | — | 100% (2) |
| Pain & inflammation % reporting improvement | 100% (4) | 80% (5) |
| Digestion % reporting improvement | 60% (15) | 43% (7) |
| Libido % reporting improvement | — | 0% (3) |
| Hormones % reporting improvement | 67% (3) | 100% (2) |
| Blood sugar % reporting improvement | 86% (58) | 88% (8) |
| Heart & lipids % reporting improvement | 92% (13) | 100% (3) |
| Skin & hair % reporting improvement | — | 33% (3) |
| Longevity % reporting improvement | 50% (2) | — |
| Common side effects | stomach issues, fatigue, constipation, anxiety | nausea, fatigue, stomach issues, constipation |
| Typical dose reported | 400-500 mg / daily | 2.4 mg / once weekly |
Treatment with berberine may be safe since it does not increase the incidence of total adverse events and the risk of hypoglycemia. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=292975, identifier CRD42021292975.
Front Pharmacol, 2022 ↗“I started berberine and inositol, and began having energy that I did not have before. Somehow, my recovery after working out wasn't as long either.”
This study shows that new anti-diabetic drugs, particularly GLP1-RA and Tirzepatide, are the most effective in inducing weight loss in patients with type 2 diabetes. Interestingly, exenatide appears to be the only GLP1-RA that induces a mild weight loss.
Pharmacol Res, 2021 ↗“I've lost 35lbs since then and now I'm in the Healthy range on BMI. My IBSD has virtually disappeared.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate