PlainPill
PeptideWeight lossPerformanceSleep

Tesamorelin

People mainly take Tesamorelin for weight loss, performance, sleep. Based on 132 first-hand reports and 3 meta-analyses & systematic reviews in the medical literature. Ranked #98 of 1,974 overall.

Compare with…Alternatives for weight loss
51
User score
Mostly positive
24% positive10% mixed5% negative61% unclear

Of reports that state an outcome, 62% are positive.

Clinical research
AStrong research base
3
meta-analyses
21
RCTs
94
papers
High-risk compound. Peptides are not approved as supplements, carry serious and sometimes irreversible risks, are banned in competitive sport and may be restricted where you live. Nothing here is a recommendation to use it.

What Tesamorelin does, according to users

Of the people who reported each effect, the share who said it got better.

Weight loss96% of 27Performance93% of 14Sleep71% of 7
5 more with fewer than 3 reports
Energy100% of 2Recovery100% of 1Appetite100% of 1Hormones100% of 1Immunity100% of 1
betterno changeworse

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

AStrong research base

3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.

J Int Assoc Provid AIDS Care · 2026 · Meta-analysis / systematic review
Efficacy and Safety of Tesamorelin in People Living With HIV (PLWH) With Lipodystrophy: A Systematic Review and Meta-Analysis

Conclusion: However, limited data on long-term safety, optimal dosing strategies, and durability of treatment effects warrant caution. Future research should evaluate extended treatment duration, dose-response relationships, and patient-reported outcomes to establish comprehensive clinical utility.

PubMed 42538058 ↗
HIV Med · 2011 · Meta-analysis / systematic review
Growth hormone axis treatments for HIV-associated lipodystrophy: a systematic review of placebo-controlled trials

Conclusion: Our review indicates that, based on the findings of the 10 included studies, GH axis treatments are effective in reducing VAT and increasing LBM in patients with HIV-associated lipodystrophy. However, clinicians must decide whether the attributed benefits are clinically significant, considering the costs and potential risks of GH axis treatments. A limitation of this study is the small number of studies available of each GH axis drug class.

PubMed 21265979 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

2 mg5 days on 2 off
1.5 mgevery other night
2 mgas reported
1 mgfirst 8 weeks
400 mcgbefore bed
1mg2x per day

Reported side effects

How often each side effect came up across all reports.

anaphylaxis ×3allergic reaction ×2elevated liver ×1insomnia ×1water retention ×1body aches ×1cramps ×1

What users say

Verbatim quotes, shortened only — each links to the original discussion.

“Tesamorelin is good for visceral fat: https://pubmed.ncbi.nlm.nih.gov/25038357/”
Source discussion ↗
“Any low blood sugar with mot or tesa?”
Source discussion ↗
“Unless it’s ozempic, monjouro, tesamorelin, or rHGH he isnt... they’re all coming out of China.”
Source discussion ↗
“I am doing Tesa/Ipa 2mg/1mg 5on/2off AM fasted.”
Source discussion ↗
“I now have my tesa early morning still fasted from Monday to Friday. My Reta Friday mornings as well. No tesa or Reta on weekends, and found my sleep improved dramatically.”
Source discussion ↗
Top discussions (5)

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User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate