NAC vs Semaglutide for appetite
Short answer: For appetite, more users report improvement with NAC — 91% of 34 reports, versus 80% of 70 for Semaglutide.
NAC has 387 meta-analyses and 767 randomized trials on PubMed; Semaglutide has 421 and 307.
Based on 2,058 reports about NAC and 330 about Semaglutide. Not medical advice.
| NAC Supplement | Semaglutide Medication | |
|---|---|---|
| Users say it helped | 54%helped947 reports · high confidence | 64%helped228 reports · high confidence |
| Verdict | Mixed | Mostly positive |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 387 / 767 | 421 / 307 |
| Mainly used for | ||
| Mood % reporting improvement | 65% (323) | 27% (11) |
| Anxiety % reporting improvement | 90% (301) | — |
| Focus % reporting improvement | 81% (170) | 60% (5) |
| Weight loss % reporting improvement | 80% (5) | 85% (138) |
| Energy % reporting improvement | 73% (91) | 39% (23) |
| Common side effects | anhedonia, stomach issues, depression, emotional blunting | nausea, fatigue, stomach issues, constipation |
| Typical dose reported | 600 mg | Not listed |
Taken together, these preliminary findings suggest that dietetic approaches might be included as part of BD treatment. Also considering the high risk of metabolic disorders in individuals with BD, they should be encouraged to choose healthy dietary lifestyles, including daily intake of fruits, vegetables, seafood and whole grains.
Nutr Neurosci, 2023 ↗“NAC has helped me stay calm and reduce anxiety as well as gives me loads of energy if I am sleep deprived.”
This study shows that new anti-diabetic drugs, particularly GLP1-RA and Tirzepatide, are the most effective in inducing weight loss in patients with type 2 diabetes. Interestingly, exenatide appears to be the only GLP1-RA that induces a mild weight loss.
Pharmacol Res, 2021 ↗“I've lost 35lbs since then and now I'm in the Healthy range on BMI. My IBSD has virtually disappeared.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate