What the science says
For 779 substances we searched PubMed for meta-analyses, systematic reviews and randomized controlled trials in humans. The grade shows how deep the research base is; each substance page shows what the reviews actually concluded.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans.
At least one meta-analysis, or 5+ randomized controlled trials.
1–4 randomized controlled trials, no meta-analysis yet.
No randomized controlled trials in humans found on PubMed.
Users ahead of science
Popular and well-rated by users, but little clinical research so far.
Science ahead of users
Heavily studied, but users report modest results.
Grade D: no human trials found
| Substance | Grade | Meta-analyses | RCTs | User score |
|---|---|---|---|---|
| Magnesium MalateSupplement | D | 0 | 0 | 66 |
| Magnesium TaurateSupplement | D | 0 | 0 | 61 |
| KlowPeptide | D | 0 | 0 | 57 |
| PhenylpiracetamSupplement | D | 0 | 0 | 56 |
| Lithium OrotateSupplement | D | 0 | 0 | 55 |
| ColuracetamSupplement | D | 0 | 0 | 53 |
| GW-501516SARM | D | 0 | 0 | 53 |
| Beet Root PowderSupplement | D | 0 | 0 | 51 |
| EpitalonPeptide | D | 0 | 0 | 51 |
| NoopeptSupplement | D | 0 | 0 | 51 |
| SabroxySupplement | D | 0 | 0 | 51 |
| Sunflower LecithinSupplement | D | 0 | 0 | 50 |
| BPC-157Peptide | D | 0 | 0 | 49 |
| RAD-140SARM | D | 0 | 0 | 48 |
| AdrafinilMedication | D | 0 | 0 | 45 |
| RacetamsSupplement | D | 0 | 0 | 45 |
| Longvida CurcuminSupplement | D | 0 | 0 | 40 |
| FlmodafinilMedication | D | 0 | 0 | 38 |
| MK-2866SARM | D | 0 | 0 | 38 |
| SunifiramSupplement | D | 0 | 0 | 37 |
| FadogiaSupplement | D | 0 | 0 | 35 |
| Black MacaSupplement | D | 0 | 0 | 34 |
| Melanotan 2Peptide | D | 0 | 0 | 34 |
| Ashwagandha (ksm-66)Supplement | D | 0 | 0 | 33 |
| CognanceSupplement | D | 0 | 0 | 33 |
| PinealonPeptide | D | 0 | 0 | 33 |
| 5-Amino-1mqSupplement | D | 0 | 0 | 32 |
| SermorelinPeptide | D | 0 | 0 | 32 |
| AnavarSubstance | D | 0 | 0 | 30 |
| Fadogia AgrestisSupplement | D | 0 | 0 | 30 |
| Dl-PhenylalanineSupplement | D | 0 | 0 | 29 |
| Bone BrothSupplement | D | 0 | 0 | 28 |
| Muira PuamaSupplement | D | 0 | 0 | 28 |
| YK-11SARM | D | 0 | 0 | 27 |
| AshwagandaSupplement | D | 0 | 0 | 26 |
| Oregano OilSupplement | D | 0 | 0 | 26 |
| Vitamin K2 MK4Supplement | D | 0 | 0 | 24 |
| AOD-9604Peptide | D | 0 | 0 | 23 |
| Tianeptine SulfateMedication | D | 0 | 0 | 23 |
| IGF-1 LR3Peptide | D | 0 | 0 | 22 |
| 7,8-DhfSupplement | D | 0 | 0 | 19 |
| Ca-AkgSupplement | D | 0 | 0 | 19 |
| CJC-1295 No DacPeptide | D | 0 | 0 | 19 |
| KlonopinMedication | D | 0 | 0 | 15 |
| RacetamSupplement | D | 0 | 0 | 15 |
| TurkesteroneSupplement | D | 0 | 0 | 13 |
| Beta-EcdysteroneSupplement | D | 0 | 0 | 11 |
Counts come from PubMed searches on the substance name in titles and abstracts; trial counts are limited to human studies. A grade reflects how much research exists, not whether the results were positive. Method details