PlainPill

Calcium

People mainly take Calcium for anxiety, mood, sleep. Based on 61 first-hand reports and 3,919 meta-analyses & systematic reviews in the medical literature. Ranked #466 of 1,974 overall.

27
User score
Mixed
15% positive8% mixed8% negative69% unclear

Of reports that state an outcome, 48% are positive.

Clinical research
AStrong research base
3,919
meta-analyses
10,361
RCTs
484,958
papers

What Calcium does, according to users

Of the people who reported each effect, the share who said it got better.

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

AStrong research base

3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.

JAMA · 2017 · Meta-analysis / systematic review
Association Between Calcium or Vitamin D Supplementation and Fracture Incidence in Community-Dwelling Older Adults: A Systematic Review and Meta-analysis

Conclusion: In this meta-analysis of randomized clinical trials, the use of supplements that included calcium, vitamin D, or both compared with placebo or no treatment was not associated with a lower risk of fractures among community-dwelling older adults. These findings do not support the routine use of these supplements in community-dwelling older people.

PubMed 29279934 ↗
Cochrane Database Syst Rev · 2024 · Meta-analysis / systematic review
Vitamin D supplementation for women during pregnancy

Conclusion: This updated review using the trustworthy assessment tool removed 21 studies from the previous update and added one new study for a total of 10 included studies. In this setting, supplementation with vitamin D alone compared to no intervention or a placebo resulted in very uncertain evidence on pre-eclampsia, gestational diabetes, preterm birth, or nephritic syndrome. It may reduce the risk of severe postpartum haemorrhage; however, only one study reported this outcome. It may also reduce the risk of low birthweight; however, the upper CI suggests that an increase in risk cannot be ruled out.

PubMed 39077939 ↗
Sci Rep · 2022 · Meta-analysis / systematic review
Outcome of pulpotomy in permanent teeth with irreversible pulpitis: a systematic review and meta-analysis

Conclusion: Stratification of teeth based on (1) symptoms demonstrated that teeth with symptomatic and asymptomatic irreversible pulpitis demonstrated success rate of 84% and 91% respectively, with no significant difference (p = 0.18) using z-score analysis; (2) open apex teeth demonstrated a significantly greater success rate (96%) compared to teeth with closed apex (83%) (p = 0.02), and (3) pulp capping materials demonstrated that Biodentine yielded significantly better success rates compared to Mineral Trioxide Aggregate (MTA), calcium hydroxide, and Calcium Enriched Mixture (CEM.) Collectively, this i

PubMed 36385132 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

200 mgdaily
250 mgwith breakfast
3000 mgdaily
1000-2000 mgdaily
morningas reported
1,000-1,200 mgas reported

Reported side effects

How often each side effect came up across all reports.

chest pain ×1brain fog ×1depression ×1fatigue ×1weakness ×1soft tissue ×1insomnia ×1

What users say

Verbatim quotes, shortened only — each links to the original discussion.

“just fish oil and magnesium/calcium/zinc, sometimes b12”
Source discussion ↗
“Dont supplement calcium, its rarely problem.”
Source discussion ↗
“Maybe try calcium with the magnesium”
Source discussion ↗
“aluminum hydroxide which prevents the absorption of calcium from the intestinal tract”
Source discussion ↗
“some studies claim healthy adults taking calcium supplements actually causes their body to absorb less calcium and then excrete more in their urine”
Source discussion ↗
Top discussions (5)

Other options for anxiety

User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate