PlainPill

Agmatine Sulfate

People mainly take Agmatine Sulfate for mood, anxiety, focus. Based on 68 first-hand reports and 0 meta-analyses & systematic reviews in the medical literature. Ranked #15 of 1,974 overall.

61
User score
Mostly positive
40% positive10% mixed4% negative46% unclear

Of reports that state an outcome, 74% are positive.

Clinical research
CLimited research
0
meta-analyses
1
RCTs
23
papers

What Agmatine Sulfate does, according to users

Of the people who reported each effect, the share who said it got better.

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

CLimited research

1–4 randomized controlled trials, no meta-analysis yet. The grade measures how much human research exists — read the conclusions below for what it found.

No meta-analyses or systematic reviews published yet — 1 randomized trials found.

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

1.5 gbefore workout
1 g2x daily
2 gnight
1.5-3 gnightly
2 grams totalmorning and early evening
0.2g-2gdaily (some 5+ years)

Reported side effects

How often each side effect came up across all reports.

anxiety ×2vivid dreams ×2drowsiness ×2ocd ×1insomnia ×1memory loss ×1depersonalization ×1cold sores ×1

What users say

Verbatim quotes, shortened only — each links to the original discussion.

“when i then take 1.5g of agmatine, i almost immediately feel ready to work out and get the sweat pumping.”
Source discussion ↗
“HRV = Agmatine Sulfate (r = +0.18)”
Source discussion ↗
“Agmatine Sulfate supplement. Apart from being awesome for your health, it'll make your farts smell like satan.”
Source discussion ↗
“I think it may have potentiated agmatine sulfate, but now I'm not so sure.”
Source discussion ↗
“I usually take anywhere from 1.5g-3g nightly when going through a period of depression. I usually start feeling better almost immediately; within 1 or 2 days.”
Source discussion ↗
Top discussions (5)

Other options for mood

User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate