PlainPill

Ashwagandha (ksm-66)

People mainly take Ashwagandha (ksm-66) for anxiety, mood, sleep. Based on 10 first-hand reports and 0 meta-analyses & systematic reviews in the medical literature. Ranked #326 of 1,974 overall.

33
User score
Mixed
30% positive40% mixed0% negative30% unclear

Of reports that state an outcome, 43% are positive.

Clinical research
DNo human trials found
0
meta-analyses
0
RCTs
0
papers

What Ashwagandha (ksm-66) does, according to users

Of the people who reported each effect, the share who said it got better.

2 more with fewer than 3 reports
betterno changeworse

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

DNo human trials found

No randomized controlled trials in humans found on PubMed. The grade measures how much human research exists — read the conclusions below for what it found.

No meta-analyses or systematic reviews published yet — 0 randomized trials found.

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

600 mgas needed
600 mgdaily
2 galmost daily
500 mg2x daily
2 months on1 month off

Reported side effects

How often each side effect came up across all reports.

depression ×2anger ×1depersonalization ×1dissociation ×1thyroid disruption ×1night sweats ×1temperature dysregulation ×1hyperthyroidism ×1

What users say

Verbatim quotes, shortened only — each links to the original discussion.

“took 2 Ksm-66 capsules (600mg) and ~800mg of elemental magnesium and wow i am extremely sedated”
Source discussion ↗
“Took KSM-66 for about 10 months and stopped because I was getting irrationally angry at everything and everyone.”
Source discussion ↗
“I'm currently dabbling with Ashwagandha (ksm 66 and Shoden) and Brahmi (Bacopa Monneri) but man nothing beats...espresso”
Source discussion ↗
“Feeels like almost all my stress is gone... My insomia is almost completely gone... This post was me my first 3-4 months on ash. Then the thyroid issues started creeping in.”
Source discussion ↗
“ash ksm-66, D3/k2 drops”
Source discussion ↗
Top discussions (5)

Other options for anxiety

User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate