People mainly take Folic Acid for focus, anxiety, sleep. Based on 16 first-hand reports and 911 meta-analyses & systematic reviews in the medical literature. Ranked #728 of 1,974 overall.
Of reports that state an outcome, 38% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: genetic, metabolic or sociodemographic) to the observed differences. These clarifications may contribute to future evidence-based guideline recommendations on monitoring and managing PCOS in the era of precision lifestyle medicine.
PubMed 35639552 ↗Conclusion: New evidence from observational studies provided additional evidence of the benefit of folic acid supplementation for preventing neural tube defects and no evidence of harms related to multiple gestation, autism, or maternal cancer. The new evidence was consistent with previously reviewed evidence on benefits and harms.
PubMed 37526714 ↗Conclusion: Data on associations of other dietary factors and ASD, ADHD and related outcomes were inconclusive and warrant future investigation. Future studies should integrate comprehensive and more objective methods to quantify the nutritional exposures and explore alternative study design such as Mendelian randomization to evaluate potential causal effects.
PubMed 31319515 ↗Conclusion: Daily oral iron supplementation during pregnancy may reduce maternal anaemia and iron deficiency at term. For other maternal and infant outcomes, there was little to no difference between groups or the evidence was uncertain. Future research is needed to examine the effects of iron supplementation on other maternal and infant health outcomes, including infant iron status, growth, and development.
PubMed 39145520 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
Verbatim quotes, shortened only — each links to the original discussion.
“I suggest taking some dna tests to see what's going on with your folic acids. Folic acids are basically like the food for your body, and a lack of them can cause health problems SUCH AS SLEEP ISSUES.”
“Folic acid can actually make people with MTHFR mutations worse since their bodies can’t adequately methylate it.”
“supplementing with Folic Acid, B1, Vitamin A + D and Fish Oil.”
“folic acid 400mcg”
“folic acid”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate