PlainPill

Phosphatidylserine

People mainly take Phosphatidylserine for sleep, anxiety, focus. Based on 215 first-hand reports and 14 meta-analyses & systematic reviews in the medical literature. Ranked #78 of 3,539 overall.

53
User score
Mostly positive
28% positive4% mixed7% negative61% unclear

Of reports that state an outcome, 72% are positive.

Clinical research
AStrong research base
14
meta-analyses
83
RCTs
18,835
papers

What Phosphatidylserine does, according to users

Of the people who reported each effect, the share who said it got better.

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

AStrong research base

3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.

J Altern Complement Med · 2021 · Meta-analysis / systematic review
Phosphatidylserine for the Treatment of Pediatric Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis

Conclusion: The effects of phosphatidylserine on overall symptoms of ADHD (ES 0.76; 95% CI: -0.07 to 1.60; p = 0.07) and hyperactivity-impulsivity (ES 0.24; 95% CI: -0.04 to 0.53; p = 0.09) were not statistically significant. Conclusions: Preliminary evidence suggests that phosphatidylserine may be effective for reducing symptoms of inattention in children with ADHD, although the quality of the evidence is low and additional research in this area is warranted.

PubMed 33539192 ↗
PLoS One · 2024 · Meta-analysis / systematic review
Safety and efficacy of antioxidant therapy in children and adolescents with attention deficit hyperactivity disorder: A systematic review and network meta-analysis

Conclusion: The rankings of safety and efficacy of the 12 antioxidants vary. Due to the low methodological quality of the included studies, the probability ranking cannot fully explain the clinical efficacy, and the results need to be interpreted with caution. More high-quality studies are still needed to verify our findings.

PubMed 38547138 ↗
Thromb Haemost · 2014 · Meta-analysis / systematic review
Anti-prothrombin (aPT) and anti-phosphatidylserine/prothrombin (aPS/PT) antibodies and the risk of thrombosis in the antiphospholipid syndrome. A systematic review

Conclusion: In conclusion, routine measurement of aPS/PT (but not aPT) might be useful in establishing the thrombotic risk of patients with previous thrombosis and/or systemic lupus erythematosus. Their inclusion as laboratory criteria for the APS should be indisputably further explored.

PubMed 24172938 ↗
Cent Nerv Syst Agents Med Chem · 2023 · Meta-analysis / systematic review
Neuronutrients and Central Nervous System: A Systematic Review

Conclusion: The areas of neurology and psychiatry have shown great advances regarding the deepening of knowledge in prophylaxis and pathophysiology, as well as in the treatment of established diseases. The recognition of the role of nutrition as an adjunct to these processes is currently growing. The search in scientific bases for neuro nutrients reveals a great growth of publications related to this theme. In the present text, some of these nutrients were explored to verify the current state of knowledge.

PubMed 36411563 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

300 mgas reported
400 mgbefore bed
150 mgdaily
300 mgnightly
dailyas reported
600-800 mgas reported

Reported side effects

How often each side effect came up across all reports.

drowsiness ×2fatigue ×2anhedonia ×1headache ×1hypotension ×1prolonged cold ×1jitteriness ×1depression ×1

What users say

First-hand experiences, quoted verbatim. We show one positive and one negative where both exist.

“A supplement I have never seen on here that works great for me is Phosphatidylserine. Somehow awesome.”
HelpedRead the discussion ↗
“Not feeling any difference.. I find it really weird I don't feel any different than I normally do.. no concentration boost or anything.”
Didn't helpRead the discussion ↗
“Phosphatidylserine (8/10): ... it made a pretty big impact as far as stress reduction for me. I felt less physical anxiety in social situations...”
HelpedRead the discussion ↗
“within 10-15 minutes if I'm feeling more down to Earth and relaxed...Over the last three weeks, I have seldom had these nervous thought loops.”
MixedRead the discussion ↗
Top discussions (5)

Other options for sleep

User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 3, 2026. How we rate