People mainly take Skullcap for anxiety, sleep, mood. Based on 29 first-hand reports and 5 meta-analyses & systematic reviews in the medical literature. Ranked #126 of 1,974 overall.
Of reports that state an outcome, 86% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
At least one meta-analysis, or 5+ randomized controlled trials. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: Besides, no severe adverse effects was identified by CHM. CHM, especially classical Chinese herbal formulas, could be used as potential candidates for COVID-19 in this battle.
PubMed 32622723 ↗Conclusion: It is believed that cranioplasty performed from 3 to 6 months after DC may significantly improve both motor and cognitive recovery.
PubMed 30280509 ↗Conclusion: Ten phytomedicines were identified as having preclinical investigations showing interaction with the GABA system, in addition to human clinical trials: kava, valerian, pennywort, hops, chamomile, Ginkgo biloba, passionflower, ashwagandha, skullcap, and lemon balm. Collectively, the literature reveals preclinical and clinical evidence for various phytomedicines modulating GABA-pathways, with comparative anxiolytic effect to the current array of pharmaceuticals, along with good safety and tolerability profiles.
PubMed 29168225 ↗Conclusion: Clinicians should be cautious regarding JHM-induced pneumonitis, particularly when using drugs/ingredients known to cause this complication, and during the early treatment period. Although most events are non-severe, critical cases should be recognized.
PubMed 28274529 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
Verbatim quotes, shortened only — each links to the original discussion.
“St. John's Wort, Passion Flower, Hops, and Skullcap. My sleep improved with those.”
“Skullcap (not with Valerian)”
“Potent anxiolytic, and potent mood-enhancing and none-cognitive-impairing effects. Similar to phenibut and kava.”
“Valerian root and skullcap are herbs that you can take to make you drowsy.”
“Thanks to skullcap lateriflora and chamomile I havent touched my diazepam 4mg in about three months.”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate