What are the side effects of Phosphatidylserine?

Users most often report drowsiness, fatigue, anhedonia, headache, hypotension. Side effects came up 10 times across 334 reports.

Phosphatidylserine side effects

Q: Is Phosphatidylserine safe?

User reports can't establish safety. PubMed lists 14 meta-analyses and 83 randomized trials. Talk to a doctor or pharmacist, especially if you take other medication.

Across 334 first-hand reports, people mentioned a side effect 10 times (about 3 per 100 reports). The most common: drowsiness, fatigue, anhedonia. User reports show what people notice — they can't tell you whether Phosphatidylserine is safe for you.

Reported side effects

drowsiness2

fatigue2

anhedonia1

headache1

hypotension1

prolonged cold1

jitteriness1

stimulation1

In their own words

“Phosphatidylserine has worked really well for anxiety. But careful with high doses, I got hypotension taking more than 400mg per day.”

HelpedRead the discussion ↗

“Not feeling any difference.. I find it really weird I don't feel any different than I normally do.. no concentration boost or anything.”

Didn't helpRead the discussion ↗

“Week 1 I was taking phosphatidylserine daily and I had 3 solid days (Wed to Sat) of calm, fear free, anxiety free living, but then I blunted cortisol too much and I couldn't stay awake.”

MixedRead the discussion ↗

“I've been trying to calm it down with Phopshatidylserine, Vit C, and Magnesium, assuming it's something to do with Cortisol or Adrenaline. But I can't seem to get it to go away.”

Didn't helpRead the discussion ↗

Is Phosphatidylserine safe? What the research covers

AResearch: Strong14 meta-analyses · 83 randomized trials on PubMed

PLoS One · 2024

Safety and efficacy of antioxidant therapy in children and adolescents with attention deficit hyperactivity disorder: A systematic review and network meta-analysis

Conclusion: The rankings of safety and efficacy of the 12 antioxidants vary. Due to the low methodological quality of the included studies, the probability ranking cannot fully explain the clinical efficacy, and the results need to be interpreted with caution. More high-quality studies are still needed to verify our findings.

Thromb Haemost · 2014

Anti-prothrombin (aPT) and anti-phosphatidylserine/prothrombin (aPS/PT) antibodies and the risk of thrombosis in the antiphospholipid syndrome. A systematic review

Conclusion: In conclusion, routine measurement of aPS/PT (but not aPT) might be useful in establishing the thrombotic risk of patients with previous thrombosis and/or systemic lupus erythematosus. Their inclusion as laboratory criteria for the APS should be indisputably further explored.