Phosphatidylcholine vs Phosphatidylserine for memory
Short answer: For memory, more users report improvement with Phosphatidylserine — 91% of 22 reports, versus 86% of 7 for Phosphatidylcholine.
Phosphatidylcholine has 45 meta-analyses and 248 randomized trials on PubMed; Phosphatidylserine has 14 and 83.
Based on 45 reports about Phosphatidylcholine and 334 about Phosphatidylserine. Not medical advice.
| Phosphatidylcholine Supplement | Phosphatidylserine Supplement | |
|---|---|---|
| Users say it helped | 54%helped6 reports · few reports | 73%helped110 reports · high confidence |
| Verdict | Not enough data | Mostly positive |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 45 / 248 | 14 / 83 |
| Mainly used for | ||
| Anxiety % reporting improvement | — | 95% (39) |
| Sleep % reporting improvement | — | 86% (37) |
| Focus % reporting improvement | 100% (2) | 96% (27) |
| Memory % reporting improvement | 86% (7) | 91% (22) |
| Mood % reporting improvement | — | 85% (13) |
| Common side effects | short term, intoxicated feeling | drowsiness, fatigue, anhedonia, headache |
| Typical dose reported | 840 mg / daily | 300 mg |
Taken together, our integrated results revealed that metabolic changes in the peripheral blood were associated with MDD, particularly decreased L-tryptophan and kynurenic acid levels, and alterations in the tryptophan-kynurenine and fatty acid metabolism pathways. Our findings may facilitate biomarker development and the elucidation of the molecular mechanisms that underly MDD.
Mol Psychiatry, 2021 ↗“I had much better luck combining citicholine, phosphatidylcholine as daily supplements”
The effects of phosphatidylserine on overall symptoms of ADHD (ES 0.76; 95% CI: -0.07 to 1.60; p = 0.07) and hyperactivity-impulsivity (ES 0.24; 95% CI: -0.04 to 0.53; p = 0.09) were not statistically significant. Conclusions: Preliminary evidence suggests that phosphatidylserine may be effective for reducing symptoms of inattention in children with ADHD, although the quality of the evidence is low and additional research in this area is warranted.
J Altern Complement Med, 2021 ↗“A supplement I have never seen on here that works great for me is Phosphatidylserine. Somehow awesome.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate