PlainPill
SupplementMoodAnxietyEnergy

Agmatine

People mainly take Agmatine for mood, anxiety, energy. Based on 140 first-hand reports and 2 meta-analyses & systematic reviews in the medical literature. Ranked #75 of 1,974 overall.

Compare with…Alternatives for mood
52
User score
Mostly positive
26% positive9% mixed6% negative59% unclear

Of reports that state an outcome, 63% are positive.

Clinical research
BModerate research base
2
meta-analyses
6
RCTs
1,868
papers

What Agmatine does, according to users

Of the people who reported each effect, the share who said it got better.

Mood89% of 36Anxiety85% of 20Energy50% of 10Sleep88% of 8Focus67% of 6Performance100% of 3
3 more with fewer than 3 reports
Libido100% of 2Memory100% of 1Pain & inflammation100% of 1
betterno changeworse

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

BModerate research base

At least one meta-analysis, or 5+ randomized controlled trials. The grade measures how much human research exists — read the conclusions below for what it found.

J Alzheimers Dis · 2019 · Meta-analysis / systematic review
Discovery of Gut Bacteria Specific to Alzheimer's Associated Diseases is a Clue to Understanding Disease Etiology: Meta-Analysis of Population-Based Data on Human Gut Metagenomics and Metabolomics

Conclusion: Levels of food-derived monoamine oxidase inhibitors and anti-bacterial compounds, the potential modulators of ADAS-bacteria growth and biogenic amine production, were altered in C&A versus NNI. ADAS is attributable to potentially modifiable risk factors of AD associated diseases.

PubMed 31561379 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

4.5 gdaily
1 gdaily
5 monthsas reported
500 mg2x daily
250 mg - 2 gas reported
eveningas reported

Reported side effects

How often each side effect came up across all reports.

drowsiness ×2vivid dreams ×2stomach issues ×2anxiety ×2irritation ×1dissociation ×1numbing ×1anger ×1

What users say

Verbatim quotes, shortened only — each links to the original discussion.

“Arginine, ginseng, agmatine, ginkgo biloba, zinc, DHEA (caution but super effective for me)”
Source discussion ↗
“Try some agmatine, citrulline, etc and see if that helps?”
Source discussion ↗
“The most side-effect free anti-depressant I've tried, it also boosts NO. Makes me more talkative and social”
Source discussion ↗
“IIRC, Silverhydra said something similar about agmatine”
Source discussion ↗
“We take about 4.5 grams of it per person, per day, no side effects.”
Source discussion ↗
Top discussions (5)

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User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate