Agmatine vs L-Theanine for mood
Short answer: For mood, more users report improvement with Agmatine — 89% of 150 reports, versus 77% of 223 for L-Theanine.
Agmatine has 2 meta-analyses and 6 randomized trials on PubMed; L-Theanine has 18 and 78.
Based on 790 reports about Agmatine and 3,475 about L-Theanine. Not medical advice.
| Agmatine Supplement | L-Theanine Supplement | |
|---|---|---|
| Users say it helped | 70%helped316 reports · high confidence | 65%helped1,807 reports · high confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | BResearch: Moderate | AResearch: Strong |
| Meta-analyses / RCTs | 2 / 6 | 18 / 78 |
| Mainly used for | ||
| Anxiety % reporting improvement | 89% (121) | 91% (1289) |
| Focus % reporting improvement | 76% (33) | 88% (501) |
| Sleep % reporting improvement | 84% (44) | 78% (370) |
| Mood % reporting improvement | 89% (150) | 77% (223) |
| Energy % reporting improvement | 70% (30) | 68% (97) |
| Common side effects | drowsiness, vivid dreams, stomach issues, dizziness | drowsiness, vivid dreams, fatigue, headache |
| Typical dose reported | 1.5 g / before workout | 200 mg / bedtime |
Levels of food-derived monoamine oxidase inhibitors and anti-bacterial compounds, the potential modulators of ADAS-bacteria growth and biogenic amine production, were altered in C&A versus NNI. ADAS is attributable to potentially modifiable risk factors of AD associated diseases.
J Alzheimers Dis, 2019 ↗“I stopped thinking about frequently killing myself, stopped going down negative thought pattern spirals, and I can actually enjoy video games for once.”
This meta-analysis provides evidence that theanine plus caffeine, and theanine alone, could be beneficial for cognitive and mood outcomes. More research using tea beverages or tea-equivalent bioactive doses and research in free-living participants is needed.
Nutr Rev, 2025 ↗“This morning was my first time taking this combination along with my other daily vitamins and wow, what a difference it has made in my overall mood and anxiety!”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate