Agmatine vs Clonidine for anxiety
Short answer: For anxiety, more users report improvement with Clonidine — 100% of 17 reports, versus 89% of 121 for Agmatine.
Agmatine has 2 meta-analyses and 6 randomized trials on PubMed; Clonidine has 311 and 1,394.
Based on 790 reports about Agmatine and 72 about Clonidine. Not medical advice.
| Agmatine Supplement | Clonidine Medication | |
|---|---|---|
| Users say it helped | 70%helped316 reports · high confidence | 63%helped30 reports · medium confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | BResearch: Moderate | AResearch: Strong |
| Meta-analyses / RCTs | 2 / 6 | 311 / 1,394 |
| Mainly used for | ||
| Mood % reporting improvement | 89% (150) | 50% (4) |
| Anxiety % reporting improvement | 89% (121) | 100% (17) |
| Sleep % reporting improvement | 84% (44) | 93% (15) |
| Performance % reporting improvement | 97% (35) | — |
| Focus % reporting improvement | 76% (33) | 100% (2) |
| Common side effects | drowsiness, vivid dreams, stomach issues, dizziness | drowsiness, depression, dizziness, anticholinergic effects |
| Typical dose reported | 1.5 g / before workout | Not listed |
Levels of food-derived monoamine oxidase inhibitors and anti-bacterial compounds, the potential modulators of ADAS-bacteria growth and biogenic amine production, were altered in C&A versus NNI. ADAS is attributable to potentially modifiable risk factors of AD associated diseases.
J Alzheimers Dis, 2019 ↗“I stopped thinking about frequently killing myself, stopped going down negative thought pattern spirals, and I can actually enjoy video games for once.”
Our findings represent the most comprehensive available evidence base to inform patients, families, clinicians, guideline developers, and policymakers on the choice of ADHD medications across age groups. Taking into account both efficacy and safety, evidence from this meta-analysis supports methylphenidate in children and adolescents, and amphetamines in adults, as preferred first-choice medications for the short-term treatment of ADHD. New research should be funded urgently to assess long-term effects of these drugs.
Lancet Psychiatry, 2018 ↗“Clonidine really helped me when I was getting off benzos. I still use it now as a replacement for when I get anxiety.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate