PlainPill

Agmatine vs L-Arginine for libido

Short answer: For libido, more users report improvement with Agmatine — 93% of 15 reports, versus 88% of 41 for L-Arginine.

Agmatine has 2 meta-analyses and 6 randomized trials on PubMed; L-Arginine has 106 and 765.

Based on 790 reports about Agmatine and 211 about L-Arginine. Not medical advice.

Agmatine
Supplement
L-Arginine
Supplement
Users say it helped70%helped316 reports · high confidence49%helped78 reports · medium confidence
Verdict
Mostly positive
Mixed
ResearchBResearch: ModerateAResearch: Strong
Meta-analyses / RCTs2 / 6106 / 765
Mainly used for
Mood
% reporting improvement
89% (150)50% (2)
Anxiety
% reporting improvement
89% (121)100% (5)
Libido
% reporting improvement
93% (15)88% (41)
Sleep
% reporting improvement
84% (44)100% (3)
Performance
% reporting improvement
97% (35)83% (12)
Common side effectsdrowsiness, vivid dreams, stomach issues, dizzinessdiarrhea, stomach issues, chest pain, tongue biting
Typical dose reported1.5 g / before workout2 g / before bed
Agmatine
Latest review conclusion

Levels of food-derived monoamine oxidase inhibitors and anti-bacterial compounds, the potential modulators of ADAS-bacteria growth and biogenic amine production, were altered in C&A versus NNI. ADAS is attributable to potentially modifiable risk factors of AD associated diseases.

J Alzheimers Dis, 2019 ↗
What a user said
“I stopped thinking about frequently killing myself, stopped going down negative thought pattern spirals, and I can actually enjoy video games for once.”
Full Agmatine profile →
L-Arginine
Latest review conclusion

Supplementation of some but not all micronutrients may benefit cardiometabolic health. This study highlights the importance of micronutrient diversity and the balance of benefits and risks to promote and maintain cardiovascular health in diverse populations. (Antioxidant Supplementation in the Prevention and Treatment of Cardiovascular Diseases; CRD42022315165).

J Am Coll Cardiol, 2022 ↗
What a user said
“Something I found that makes my meds work way better is Citrulline 2g + Arginine 2g twice daily.”
Full L-Arginine profile →

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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate