Agmatine vs Creatine for mood
Short answer: For mood, users rate them about the same: 89% report improvement with Agmatine (150 reports) and 87% with Creatine (125 reports).
Agmatine has 2 meta-analyses and 6 randomized trials on PubMed; Creatine has 763 and 2,794.
Based on 790 reports about Agmatine and 2,279 about Creatine. Not medical advice.
| Agmatine Supplement | Creatine Supplement | |
|---|---|---|
| Users say it helped | 70%helped316 reports · high confidence | 72%helped1,048 reports · high confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | BResearch: Moderate | AResearch: Strong |
| Meta-analyses / RCTs | 2 / 6 | 763 / 2,794 |
| Mainly used for | ||
| Performance % reporting improvement | 97% (35) | 98% (542) |
| Energy % reporting improvement | 70% (30) | 97% (268) |
| Focus % reporting improvement | 76% (33) | 93% (249) |
| Mood % reporting improvement | 89% (150) | 87% (125) |
| Anxiety % reporting improvement | 89% (121) | 64% (25) |
| Common side effects | drowsiness, vivid dreams, stomach issues, dizziness | stomach issues, hair loss, insomnia, water retention |
| Typical dose reported | 1.5 g / before workout | 5 g / daily |
Levels of food-derived monoamine oxidase inhibitors and anti-bacterial compounds, the potential modulators of ADAS-bacteria growth and biogenic amine production, were altered in C&A versus NNI. ADAS is attributable to potentially modifiable risk factors of AD associated diseases.
J Alzheimers Dis, 2019 ↗“I stopped thinking about frequently killing myself, stopped going down negative thought pattern spirals, and I can actually enjoy video games for once.”
The results of the meta-analysis suggest that creatine supplementation did not significantly alter serum creatinine levels (standardized mean difference = 0.48, 95% confidence interval 0.24-0.73, P = .001, I2 = 22%), and did not alter plasma urea values (standardized mean difference = 1.10, 95% confidence interval 0.34-1.85, P = .004, I2 = 28%). The findings indicate that creatine supplementation does not induce renal damage in the studied amounts and durations.
J Ren Nutr, 2019 ↗“I actually feel a lot better. Mentally clearer and more balanced, like I have my brain back.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate