Agmatine vs Memantine for mood
Short answer: For mood, more users report improvement with Memantine — 95% of 41 reports, versus 89% of 150 for Agmatine.
Agmatine has 2 meta-analyses and 6 randomized trials on PubMed; Memantine has 236 and 311.
Based on 790 reports about Agmatine and 274 about Memantine. Not medical advice.
| Agmatine Supplement | Memantine Medication | |
|---|---|---|
| Users say it helped | 70%helped316 reports · high confidence | 54%helped101 reports · high confidence |
| Verdict | Mostly positive | Mixed |
| Research | BResearch: Moderate | AResearch: Strong |
| Meta-analyses / RCTs | 2 / 6 | 236 / 311 |
| Mainly used for | ||
| Mood % reporting improvement | 89% (150) | 95% (41) |
| Anxiety % reporting improvement | 89% (121) | 88% (25) |
| Focus % reporting improvement | 76% (33) | 81% (32) |
| Sleep % reporting improvement | 84% (44) | 0% (4) |
| Performance % reporting improvement | 97% (35) | — |
| Common side effects | drowsiness, vivid dreams, stomach issues, dizziness | dizziness, dissociation, insomnia, confusion |
| Typical dose reported | 1.5 g / before workout | Not listed |
Levels of food-derived monoamine oxidase inhibitors and anti-bacterial compounds, the potential modulators of ADAS-bacteria growth and biogenic amine production, were altered in C&A versus NNI. ADAS is attributable to potentially modifiable risk factors of AD associated diseases.
J Alzheimers Dis, 2019 ↗“I stopped thinking about frequently killing myself, stopped going down negative thought pattern spirals, and I can actually enjoy video games for once.”
ChEIs, memantine, and GV-971 all can slow the progression of AD but have different effects on respective assessments. Donepezil and GV-971 were relatively well tolerated.
Medicine (Baltimore), 2024 ↗“I feel like I have all the positives of Adderall (focus, motivation, mood increase) without any noticeable downsides. No crash, no anxiety, no cardiac issues.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate