PlainPill

What people actually say

975 first-hand quotes, shortened but never edited — each links to the original discussion.

AllWeight lossAppetiteFocusEnergySleepAnxietyMoodMemoryPerformanceRecoveryPain & inflammationDigestionLibidoHormonesBlood sugarHeart & lipidsSkin & hairImmunityLongevity
SemaglutideMostly positive
“I've lost 35lbs since then and now I'm in the Healthy range on BMI. My IBSD has virtually disappeared.”
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SemaglutideMostly positive
“I tried ozempic at first. Made me really sick so I stopped.”
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SemaglutideMostly positive
“I recently cycled off Ozempic after 6 months. It did not agree with me...profund depression...profound depression(something I dont normally have an issue with).”
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SemaglutideMostly positive
“I’ve noticed since getting on the wegovy I have felt like I’ve been in a strange depression. I’m not explicitly suicidal but I feel nothing - no happiness, no love, no hope.”
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TianeptineMostly positive
“It has really improved the quality of my life, more than anything else I have taken.”
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TianeptineMostly positive
“it made my head foggy and made me more anxious. Noticed no improvement in mood.”
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TianeptineMostly positive
“I take 15mg 3x daily, and it keeps me out of depression and in a good mood. It also helps me focus in class more.”
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TianeptineMostly positive
“I was able to successfully quit using low doses of tianeptine. But be careful as that can be an even worse addiction.”
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CistancheMostly positive
“Cistanche extract increases my drive, energy and vigor. It makes me want to attack life. I get better sleep...My work ethic has improved. My memory. my attitude towards life. Every facet of my life has been altered in a positive meaningful way.”
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CistancheMostly positive
“Fucking hated it. After just a week on it my libido went non existent. It left me feeling numb, unmotivated and lazy.”
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CistancheMostly positive
“Increases energy, boosts my mood, makes me feel more chilled, better libido, I feel more confident.”
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CistancheMostly positive
“cistanche is the only thing I had to stop taking because it worked too well...cistanche is the only thing that made me horny all the time.”
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ZMAMostly positive
“The only thing that is affordable and has seemed to help me is ZMA. I only have the anecdote that ZMA seemed to improve sex drive, sleep, dreams, erectile quality when I first t began taking it at age 18.”
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ZMAMostly positive
“So then I started taking ZMA since I read it does wonders for energy and helps ensure proper sleep. I proceeded to feel worse, anhedonic and basically depressed.”
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ZMAMostly positive
“supplementing ZMA, D3, creatine, sardines/DHA&EPA/other fatty fish works well for my health, sleep, and muscle gain.”
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ZMAMostly positive
“my sleep quality has improved tremendously. It's hard to put into words but I feel like I'm sleeping on clouds. I'm also sleeping fewer hours but feeling more rested in the morning.”
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ALAMostly positive
“I also take alcar, alpha lipoic acid, choline, and pqq, but... there is some difference with these, but not as major as with CoQ10.”
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ALAMostly positive
“ALCAR+alpha lipoic acid works as well as Adderall. Actually, it's a bit better for me—it wears off more slowly and doesn't interfere with sleep the way Adderall does.”
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ALAMostly positive
“ALA fixed the issue almost instantly, so I usually don't take ALCAR without the ALA.”
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ALAMostly positive
“R-ALA - has shrunk keloids that I was told would never go away and helped with general over all MS body pain”
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PsilocybinMostly positive
“Mushrooms make me a better husband and a better human all around. Sometimes I don’t feel the urge to have sex while I’m on a dose, but I feel much more connected afterward. Low dose is definitely an aphrodisiac in my experience.”
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PsilocybinMostly positive
“doing shrooms helped a lot. I felt really peaceful...This slowly went away, and was gone the next day.”
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PsilocybinMostly positive
“I also micro dose psilocybin on and off and macro dose once in awhile. This definitely helps with my overall well-being and mood.”
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PsilocybinMostly positive
“The psilocybin just made my mind quieter and allowed me to focus on one thing at a time. Its also helped me just stay in a positive mood which helped my anxiety.”
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“Within hours of consumption my consistent upper back pain is literally gone, but along with it comes dizziness and a feeling of aloofness.”
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“My knees were getting rather janky and then I started the collagen and in a few months, they were 95 percent better.”
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“I stopped taking collagen powder after years... I used to find I'd get a histmaine episode after taking it sometimes, and get the lethargy.”
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“after a couple of weeks of it I get super energised...and my anxiety is much reduced.”
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FolateMostly positive
“I have been taking methylfolate with methylcobalamin for almost two months now and my prefrontal abilities with respect to planning and stress management have improved dramatically.”
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FolateMostly positive
“I tried so many things for depression like saffron rhodiola tyrosine omega 3 methylfolate B12 taurine theanine NAC inositol b complex magnesium nothing helps it.”
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FolateMostly positive
“The first couple times I took methylfolate I felt better and more energetic than ever before...after about 6 months experimenting I would say it has had a good overall effect and I do feel quite a bit better.”
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FolateMostly positive
“I couldn't take any amount of methyl-B12 or Methylfolate without feeling like absolute crap.”
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SAM-EMostly positive
“I also take SAM-e in the morning (200mg or 400mg per day depending on how I'm feeling) for my general depression/anxiety.”
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SAM-EMostly positive
“I just started taking Sam-e and it’s helped with my ADHD and depression tremendously.”
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SAM-EMostly positive
“Taking SAM-e completely changed my life from total lethargy with the only relief being Adderall or Ritalin to being a functional person, no side effects noticed and I only have to cycle it occasionally.”
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SAM-EMostly positive
“SAMe and agmatine sulfate over the past year to be the two most noticeably helpful supplements i have ever taken for baseline energy/mood.”
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“Quercetin and bromelain, Vitamin K and D, astaxanthan, fish oil, turmeric, boron, msm, and coq10. I have osteoarthritis and this combo has been helping with the pain.”
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“The Thorne Quercetin has helped me a lot with seasonal allergies. I'd go as far as to say it had been more effective for me than either Claritin or Zyrtec.”
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“Quercetin. I had it against Covid, but apparently it is also good for allergies. It worked.”
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“I feel like it does help against allergies and cold and flu season.”
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