Conclusion: Our results showed that robotic surgery contributed positively to some perioperative outcomes but longer operative times remained a shortcoming. Better quality evidence is needed to guide surgical decision making regarding the precise clinical targets of this innovation in the next generation of its use.
PubMed 26895896 ↗SAM-E
People mainly take SAM-E for mood, energy, anxiety. Based on 107 first-hand reports and 3 meta-analyses & systematic reviews in the medical literature. Ranked #63 of 1,974 overall.
Of reports that state an outcome, 64% are positive.
What SAM-E does, according to users
Of the people who reported each effect, the share who said it got better.
5 more with fewer than 3 reports
What the research says
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
At least one meta-analysis, or 5+ randomized controlled trials. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: Peer support and/or self-directed support resources may be valuable mechanisms for supporting Autistic people to cultivate a positive Autistic identity. The evaluation of such support, including the long-term impacts on identity development, will be a critical avenue for future research.
PubMed 38334318 ↗Conclusion: For MDD of mild to moderate severity, exercise, light therapy, St. John's wort, omega-3 fatty acids, SAM-e, and yoga are recommended as first- or second-line treatments. Adjunctive exercise and adjunctive St. John's wort are second-line recommendations for moderate to severe MDD. Other physical treatments and natural health products have less evidence but may be considered as third-line treatments. CAM treatments are generally well tolerated. Caveats include methodological limitations of studies and paucity of data on long-term outcomes and drug interactions.
PubMed 27486153 ↗Dosage people report
As stated by users — not a recommendation. Follow the label or your doctor.
Reported side effects
How often each side effect came up across all reports.
What users say
Verbatim quotes, shortened only — each links to the original discussion.
“S-adenosylmethionine (SAM-e) is as effective as nonsteroidal anti-inflammatory drugs in reducing pain and disability from knee osteoarthritis”
“Recently she asked me if I knew anything about Sam-e and if she should get it but I wasn't sure.”
“I just started taking Sam-e and it’s helped with my ADHD and depression tremendously.”
“SAMe and agmatine sulfate over the past year to be the two most noticeably helpful supplements i have ever taken for baseline energy/mood.”
“gamma aminobutyric acid (GABA), and S-adenosylmethionine (SAMe)”
Top discussions (5)
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Other options for mood
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate