PlainPill

Folate

People mainly take Folate for mood, energy, focus. Based on 51 first-hand reports and 744 meta-analyses & systematic reviews in the medical literature. Ranked #132 of 1,974 overall.

48
User score
Mostly positive
20% positive4% mixed2% negative75% unclear

Of reports that state an outcome, 77% are positive.

Clinical research
AStrong research base
744
meta-analyses
1,173
RCTs
34,707
papers

What Folate does, according to users

Of the people who reported each effect, the share who said it got better.

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

AStrong research base

3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.

Nutr Rev · 2022 · Meta-analysis / systematic review
B vitamins and prevention of cognitive decline and incident dementia: a systematic review and meta-analysis

Conclusion: This meta-analysis suggests that B vitamin supplementation is associated with slowing of cognitive decline, especially in populations who received early intervention and intervention of long duration; the study also indicates that higher intake of dietary folate, but not B12 or B6, is associated with a reduced risk of incident dementia in non-dementia aged population. Given the prevalence of dementia cases in many countries with aging populations, public health policies should be introduced to ensure that subgroups of the population at risk have an adequate B vitamin status.

PubMed 34432056 ↗
Nutrients · 2021 · Meta-analysis / systematic review
Nutrient Intake and Status in Adults Consuming Plant-Based Diets Compared to Meat-Eaters: A Systematic Review

Conclusion: There were nutrient inadequacies across all dietary patterns, including vegan, vegetarian and meat-based diets. As plant-based diets are generally better for health and the environment, public health strategies should facilitate the transition to a balanced diet with more diverse nutrient-dense plant foods through consumer education, food fortification and possibly supplementation.

PubMed 35010904 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

400 mcgwith breakfast
dailyas reported
200-800 µgas reported
400-1000 mcgdaily
1360 mcgas reported
500ugsplit into 4 doses

Reported side effects

How often each side effect came up across all reports.

insomnia ×2canker sores ×1anxiety ×1

What users say

Verbatim quotes, shortened only — each links to the original discussion.

Other options for mood

User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate