What people actually say
2,084 first-hand quotes, shortened but never edited — each links to the original discussion.
AllWeight lossAppetiteFocusEnergySleepAnxietyMoodMemoryPerformanceRecoveryPain & inflammationDigestionLibidoHormonesBlood sugarHeart & lipidsSkin & hairImmunityLongevity
L-DopaMixed
“I find 4-hydroxyphenylalanine and L-γ-glutamylethylamide make a huge difference in keeping myself on an even keel..”Source discussion ↗
L-DopaMixed
“L-Dopa is making me a bit anxious but sure helps me with depression and focus.”Source discussion ↗
L-DopaMixed
“I have been taking L-Dopa and it has been working for me. My moods have been consistent and my anxiety have been almost non-existent.”Source discussion ↗
L-DopaMixed
“I've taken both L-Dopa and 5-HTP before and they didn't do shit.”Source discussion ↗
SarcosineMostly positive
“sarcosine + NAC nailed it. I literally cannot tell the difference. I feel so amazing.”Source discussion ↗
SarcosineMostly positive
“long courses of Sarcosine (daily for a month+ at a time) helped tremendously and permanently, however when I tried it again more recently it triggered anxiety and overthinking.”Source discussion ↗
SarcosineMostly positive
“GlyT1 Inhibitors: Sarcosine and (lesser extent) dimethylglycine cause glycine reuptake inhibition, proven quite effective for anxiety ... Helps me a lot.”Source discussion ↗
SarcosineMostly positive
“2000mg sarcosine helps with the emotional blunting often seen in schizophrenia, and it aids cognitive performance through enhanced NMDA signaling. I have taken both for a few weeks and they have helped me tremendously.”Source discussion ↗
Resistance TrainingMostly positive
“more weight training. I was pumping iron, but not often enough so I lost more muscle mass than what I needed to.”Source discussion ↗
Resistance TrainingMostly positive
“I find resistance training especially effective. Quads, glutei, calves, triceps, biceps, shoulders, abs - get them all reasonable sore, and you crash like a baby.”Source discussion ↗
Resistance TrainingMostly positive
“I made incredible strides and even worked through the right shoulder issue that had been hampering me for years.”Source discussion ↗
Resistance TrainingMostly positive
“my hack to get it up without pharmaceuticals and have increased libido. Is doing lots of squats with weights”Source discussion ↗
DihexaMostly positive
“The effects have been promising, because I found myself not only better in actual routine work, but also studying and learning, which was really hard to me before. It felt like combining mental clarity with neural plasticity.”Source discussion ↗
DihexaMostly positive
“I've taken it three times, all orally. It's easily the most profound substance i've tried yet...Better memory and general retention, greater plasticity...improved physical performance”Source discussion ↗
DihexaMostly positive
“fish oil psilocybin dihexa and fast for at least 24 hrs once per week... these are the things i feel were absolutely critical in my recovery.”Source discussion ↗
DihexaMostly positive
“some peptides like dihexa, Cerebrolysin, selank, semax, and Retatrutide also helped my recovery”Source discussion ↗
VenlafaxineMixed
“I really got better from anxiety ... on effexor. My personal miracle drug does not work for everyone.”Source discussion ↗
VenlafaxineMixed
“I tried Venlafaxine and my ADHD improved significantly. However, it also had a certain amount of excitotoxicity, and I couldn't sleep at night.”Source discussion ↗
VenlafaxineMixed
“I started Venlafaxine three months ago when I got depressed again...and it got me out of bed, but NAC was the game changer for me.”Source discussion ↗
VenlafaxineMixed
“I found that Venlafaxine was good once it down regulated my norephineprine. Before I was constantly full of somatic anxiety but now it’s definitely improved.”Source discussion ↗
Tribulus TerrestrisMixed
“took the tribulus, and 30 minutes later I jumped out of bed with a massive amount of energy and drive to go do stuff.”Source discussion ↗
Tribulus TerrestrisMixed
“List of things I've tried (some worked, but only for a few days and then never worked again)”Source discussion ↗
Tribulus TerrestrisMixed
“ND Trib/Now Trib did gave me sides over time : worse sleep , frequent pee urge ( i guess irritated prostate/bladder from higher dht )”Source discussion ↗
Tribulus TerrestrisMixed
“I also started trying the ND Tribulus and it gives me extra physical energy, but a sort of aggressive energy.”Source discussion ↗
SSRIMostly negative
“then i came to SSRI , it helped a little bit then.”Source discussion ↗
SSRIMostly negative
“I only took them for those 25 days and quit because it made me feel 100% numb with zero emotions or pleasure.”Source discussion ↗
SSRIMostly negative
“Started doing some therapy and an SSRI, and saw huge improvement in all my symptoms.”Source discussion ↗
SSRIMostly negative
“I decided to try an SSRI one day and now my life has completely changed. Anxiety is gone, obsessive behavior/rituals are gone, agoraphobia is gone.”Source discussion ↗
TribugenMostly positive
“I m getting great energy and insane libido EVERYDAY. I m 44.”Source discussion ↗
TribugenMostly positive
“Taking 4 capsules in a day is where I started to feel really good, but just without the energy difference.”Source discussion ↗
TribugenMostly positive
“if i take them individually , the effects are not much. in-fact i don't feel anything. But if you combine them, it's magic.”Source discussion ↗
IbuprofenMostly positive
“I've always had a positive response to ibuprofen and would take it morning and night if it wasn't for the side effects and agmatine provides the same anti-depressant effects of ibuprofen.”Source discussion ↗
IbuprofenMostly positive
“I take 1600mgs of advil and a 100mgs of zinc supplements a night. Have noticed absolutely nothing. Except better sleep.”Source discussion ↗
IbuprofenMostly positive
“I find curcumin works just as well, if not better, than ibuprofen.”Source discussion ↗
IbuprofenMostly positive
“I tried paracetamol, ibuprofen, tramadol(all painkillers) and methyl salicylate to decrease inflammation prescribed by my doctor but nothing is working.”Source discussion ↗
MDMAMixed
“I feel that MDMA changed my personality forever, in a good way.”Source discussion ↗
MDMAMixed
“Probably great for PTSD but it did nothing really for me. I mean great experience but against depressive or anxiety symptoms it doesn't do shit long-term.”Source discussion ↗
MDMAMixed
“I took my 200mg dose and felt absolutely nothing. The only thing I got out of it was the inability to sleep, and urinate.”Source discussion ↗
MDMAMixed
“Fantastic. Helped my think through alot of the things I was ruminating over.”Source discussion ↗
ThiamineMostly positive
“I'll take a little extra (esp of b1) and physically feel calmer within the hour.”Source discussion ↗